肿瘤相关性炎症导致术后认知功能障碍的研究进展

Current progress on the relationship between inflammation and postoperative cognitive dysfunction

术后认知功能障碍(postoperative cognitive dysfunction,POCD)是患者在全身麻醉手术后出现的中枢神经系统损害,其危险因素及诱发因素非常复杂,具体机制尚不清楚。近年来,炎症反应在POCD发生、发展中的作用越来越受到重视,且有研究发现肿瘤引起的相关性炎症也起了重要作用。现以围术期炎症反应作为切入点,对其在POCD发生、发展中的作用及围术期麻醉药物及麻醉方法对炎症反应及POCD的影响作一综述,以期深入了解POCD的发生机制,为肿瘤患者中POCD的高危人群麻醉药物和麻醉方法的选择提供理论依据和参考。

Postoperative cognitive dysfunction （POCD） is a serious central nervous system complication after general anesthesia and surgery. Its risk factors are very complex, and the mechanisms of POCD are still unclear. Recently, the role of inflammation, especially cancer related inflammation, in the development of POCD is of great interest. In this review, we focus on inflammation, and try to clarify the effect of anesthetics and anesthesia on inflammation and POCD. This review aimed to provide a theoretical basis of choosing appropriate anesthetics and anesthesia for these patients, especially the cancer patients, who are vulnerable to inflammation and POCD.