胆囊癌淋巴转移机制研究进展

The progress research on the mechanism of lymphatic metastasis in gallbladder cancer

胆囊癌是胆道系统最常见的恶性肿瘤,其发现和患者就诊一般较晚,手术切除率低,疗效较差.淋巴转移是胆囊癌最常见的转移方式,并且影响患者的手术方式和预后.加强对胆囊癌淋巴转移机制的基础研究,对于探索胆囊癌的治疗及改善预后具有重要意义.本文就胆囊癌淋巴转移的常见分子机制及淋巴管标志物等方面的研究进展作一综述.

Gallbladder cancer （GBC） is the most common malignancy tumor in bile duct system, since its early symptoms are not obvious, most patients are diagnosed at the advanced stage, missing the optimal chance for curative surgery, thus leading to poor prognosis.Lymphatic metastasis is the most common way in GBC and it influence the operation method and prognosis.It is significant to strengthen the fundamental research of GBC lymphatic metastasis, in order to explore the treatment and evidence improve prognosis.The familiar molecular mechanism in GBC lymphatic metastasis and the markers of lymphatic vessel were reviewed in this paper.