β2-转铁蛋白在神经外科颅内感染诊断中的研究

The diagnostic value of cerebrospinal fluids β-2transferrin for neurosurgical intracranial infection

目的探究、评估脑脊液特异的β2-转铁蛋白(β-2transferrin,β-2Tf)在早期诊断神经外科术后颅内感染中的应用价值。方法选取64例北京天坛医院神经外科术后的病人,根据病人的症状及实验室检查分为感染组和非感染组,其中感染组23例,非感染组41例,检测其脑脊液β2-转铁蛋白,并计算其与脑脊液总蛋白的比值。结果感染组β2-转铁蛋白明显高于非感染组,差异有统计学意义(P<0.001),β2-转铁蛋白与脑脊液总蛋白比值在感染组也高于非感染组(P<0.05)。结论脑脊液β2-转铁蛋白在神经外科术后颅内感染的诊断中具有重要的意义。

Objective To explore the differential diagnostic value ofβ-2transferrin in cerebrospinal fluids（CSF）for bacterial meningitis in adult brain tumor neurosurgery.Methods 64 patients with suspected intracranial infection after neurosurgery were enrolled,the patients were classified as intracranial infection group（n=23）,and non intracranial infection group（n=41）according to patient＇s symptom and laboratory results.we tested the cerebrospinal fluid level ofβ-2transferrin and calculated the ratio ofβ-2transferrin to total CSF protein.Results The levels ofβ-2transferrin in infection group were significantly higher than those of the non-infection group（P〈0.001）.The cut-off values（sensitivity and specificity）ofβ-2transferrin were 18.47mg/L（82.6%、85%）The same result was happened in calculating the ratio ofβ-2Tf to protein（P〈0.05）.Conclusion β-2transferrin is expected to be a novel biomarker for the diagnosis of intracranial infection.