降钙素原、C反应蛋白及白细胞计数在儿童中枢神经系统感染性疾病诊断中的应用价值

Procalcitonin and C reactive protein and white blood cell count and other indicators in monitoring to investigate the application value of diseases in the central nervous system infection in children

目的探讨降钙素原(PCT)、C反应蛋白(CRP)及白细胞计数(WBC)在儿童中枢神经系统感染性疾病中的诊断价值。方法选取中枢神经系统感染患儿100例,根据感染致病菌不同分为化脓组和病毒组,每组各50例,观察两组患儿血清和脑脊液中白细胞计数、C反应蛋白、降钙素原及乳酸脱氢酶(LHD)含量,同时观察比较两种检验标本阳性率。结果两组患儿入院时和恢复期脑脊液中CRP、PCT、LHD水平,明显低于同组血清中含量;化脓组患儿入院时和恢复期脑脊液中WBC水平,明显低于血清中水平,差异有统计学意义(P<0.05);化脓组患儿入院时和恢复期血清、脑脊液中WBC、CRP、PCT、LHD水平,均明显高于病毒组患儿水平,差异有统计学意义(P<0.05)。化脓组患儿入院时血清、脑脊液中WBC、CRP、PCT、LHD水平阳性率,均明显高于病毒组同样本阳性率,差异有统计学意义(P<0.05)。结论中枢神经系统感染性疾病患儿如血清CRP、PCT、LHD均为阳性,即可确诊为细菌感染,可避免腰穿,方便易行,值得推广应用。

Objective To investigate the diagnostic value of the Procalcitonin、C reactive protein and white blood cell count in children with central nervous system infection.Methods Select the central nervous system infection in 100 cases with infectious pathogens were divided into purulent virus group and 50 cases in each group.The observation group of two different pathogenic bacteria of children in the hospital,the white blood cell count in serum and cerebrospinal fluid in acute stage（WBC）,C reactive protein（CRP）,calcitonin peptide（PCT）and lactate dehydrogenase（LHD）content,and two kinds of test specimens the positive rate of observation.Results Two groups of children in the hospital and restore the CRP,PCT,LHD level in CSF was significantly lower than that with the content of serum;septic groups at admission and restore the level of WBC in CSF was significantly lower than the level in the serum,the difference was statistically significant（P〈0.05）;septic groups at admission and recovery in serum and cerebrospinal fluid WBC,CRP,PCT and LHD levels were significantly higher than that of the virus group,the difference was statistically significant（P〈0.05）.The positive rates of WBC,CRP,PCT,LHD in serum and cerebrospinal fluid of the patients with purulent group were significantly higher than those in the same group of virus group,the difference was statistically significant（P〈0.05）.Conclusion Children with central nervous system infectious diseases,such as serum CRP,PCT,LHD were positive,can be diagnosed as bacterial infection,lumbar puncture can be avoided,convenient and easy to operate.