绝经前和绝经后患者血红蛋白及血清铁蛋白含量的检测及其意义分析

Detection and clinical significance of hemoglobin and serum ferritin in premenopausal and postmenopausal women

目的观察血红蛋白(Hb)、血清铁蛋白(SF)含量检测在绝经期前后女性患者贫血诊断中的应用价值。方法选取2015年7月-2016年7月我院妇科住院部收治的84例女性患者作为观察对象,其中绝经期前50例,绝经期后34例;异常子宫出血19例,非异常子宫出血65例。术前对患者进行SF、Hb水平检测,分析SF、Hb水平对异常子宫出血、缺铁性贫血相关性。结果 84例患者中SF水平明显降低有22例(26.19%),术前贫血有17例(20.14%);绝经期前50例患者中SF水平明显降低有19例(38.00%),缺铁性贫血有16例(32.00%);绝经期后34例患者中SF水平明显降低3例(8.82%),缺铁性贫血有1例(2.94%);绝经期前患者的SF、Hb水平明显低于绝经期后患者,差异有统计学意义(P<0.05)。异常子宫出血患者的SF、Hb水平明显低于非异常子宫出血患者(P<0.05)。Pearson结果显示Hb与SF水平存在正相关关系(r=0.320,P=0.0030)。SF水平诊断异常子宫出血时曲线下的面积(AUC)为0.8636,95%置信区间0.7733-0.9538(P<0.0001),灵敏度可达69.23%,特异度高达89.47%;Hb诊断异常子宫出血时曲线下的面积(AUC)为0.9405,95%置信区间0.8936-0.9874(P<0.0001),灵敏度可达80.00%,特异度高达100.00%。结论绝经期前女性贫血发生率明显高于绝经期后,对患者进行SF、Hb水平检测可以了解患者有无贫血情况,对治疗方案的选择具有重要的指导意义。

Objective To evaluate the diagnostic value of serum hemoglobin（Hb）and serum ferritin（SF）in anemic women before and after menopause.Methods 84 female patients admitted to our hospital from July,2015 to July,2016 were selected,including 50 cases before menopause and 34 cases after menopause.SF and Hb levels were analyzed for abnormal uterine bleeding and iron deficiency anemia.Results There were 22（26.19%）with asiderosis in the 84 patients and 17（20.14%）cases with anemia.In the 50 cases before menopause,the SF level was significantly decreased in19cases（38.00%）,iron deficiency（32.00%）in anemia,and in 3patients（8.82%）and 1in iron deficiency anemia（2.94%）.The levels of SF and Hb in premenopausal women were significantly lower than those in postmenopausal women（P〈0.05）in postmenopausal patients.The levels of SF and Hb in patients with abnormal uterine bleeding were significantly lower than those in patients with abnormal uterine bleeding（P〈0.05）.Pearson＇s results showed a positive correlation between Hb and SF（r= 0.320,P= 0.0030）.The level of SF in the diagnosis of abnormal uterine bleeding（AUC）was 0.8636,95% confidence interval 0.7733-0.9538（P〈0.0001）.The sensitivity was 69.23% and the specificity was 89.47%.The level of Hb in the diagnosis of abnormal uterine bleeding was（AUC）was 0.9405,95% confidence interval 0.8936-0.9874（P〈0.0001）,the sensitivity was 80.00% and the specificity was as high as100.00%.Conclusion The incidence of anemia in premenopausal women was significantly higher than that in postmenopausal women,and the decrease was larger.The detection of SF and Hb levels in patients with anemia can be an important indicator to the choice of treatment regimen.