NCT监测用于七氟醚麻醉下气管内插管时麻醉深度变化的可行性研究

Feasibility study on the depth of anesthesia monitoring under sevoflurane anesthesia endotracheal intubation for monitoring NCT

目的探讨NTC监测七氟醚麻醉下气管内插管时麻醉深度变化的临床研究。方法选取我院2014年1月至2015年1月的150例择期行全麻下气管插管妇科手术患者,SASⅠ级或Ⅱ级,随机分为A、B两组,每组75例,A组单纯七氟醚诱导,B组七氟醚联合罗库溴铵诱导。采用多功能心电监护仪及Narcotrend麻醉深度监测仪对两组患者进行监测,观察麻醉过程中的NCT、BIS(脑电双频谱指数)、MAR(平均动脉压)、HR(心率)等。结果两组患者的MAP、HR在插管前的差异无统计学意义(P>0.05)。插管后A组(单药组)MAP、HR的上升幅度比B组(联合用药组)大(P<0.05)。两组患者诱导前(T1)的NCT、BIS值没有差别(P>0.05)。诱导后两组的NCT、BIS均比诱导前低(P<0.05)。结论 NCT在单纯七氟醚麻醉诱导过程中能反映气管内插管伤害性刺激所导致的麻醉深度变化。

Objective To explore the clinical study of changes of the depth of anesthesia monitoring NTC endotracheal intubation in sevoflurane anesthesia.Methods 150 patients undergoing general anesthesia endotracheal intubation in patients undergoing gynecological surgery SAS grade I or II randomly divided into two groups：group A and group B,75 cases in each group,group A was treated with sevoflurane induction,group B sevoflurane combined with rocuronium induction.Anesthesia depth monitoring of patients in the two groups were monitored by multi functional ECG monitor and Narcotrend,observation of anesthesia in the process of NCT,bis（bispectral index）,Mar（mean arterial pressure）,HR（heart rate）.Results There was no significant difference in MAP and HR between the two groups before intubation（P〉0.05）.After intubation,A group（single drug group）HR,MAP increased significantly compared with group B（combined group）（P〈0.05）.There was no difference in NCT and BIS values between the two groups before induction（P〉0.05）（T1）.The NCT and BIS of the two groups after induction were lower than before（P〈0.05）.Conclusion NCT in sevoflurane anesthesia induction process can reflect the endotracheal intubation noxious stimulation causes the depth of anesthesia.