斑蝥酸钠维生素B6注射液对非小细胞肺癌手术患者血清VEGF水平的影响

Effect of Cantharis Acid Sodium Vitamin B6 Injection on serum VEGF level in NSCLC surgical patients

目的观察非小细胞肺癌(NSCLC)手术患者术前应用斑蝥酸钠维生素B6注射液,通过抑制肿瘤的复发和转移,改善NSCLC手术患者的愈后。方法将38例经穿刺活检或气管镜活检证实为非小细胞肺癌的患者随机分为两组,治疗组(22例)给予斑蝥酸钠维生素B6注射液治疗5d;对照组16例使用未加药物的0.9%氯化钠注射液。应用双抗体夹心ELISA法检测治疗前后血清血管内皮细胞生长因子(s-VEGF)浓度。结果术前使用斑蝥酸钠维生素B6注射液能降低非小细胞肺癌患者血清VEGF水平(P<0.05)。结论使用斑蝥酸钠维生素B6注射液,可通过降低血清VEGF水平,从而达到抑制非小细胞肺癌的复发和转移的可能,提高NSCLC手术患者的疗效。

Objective To investigate the effect of preoperative application of Cantharis Acid Sodium Vitamin B6 Injection on recurrence and metastasis of non-small cell lung cancer （NSCLC） and the prognosis of the patients. Methods Thirty-eight cases of NSCLC confirmed by Meddle biopsy or bronchoscopic biopsy were randomly divided into treatment group （22 cases） and control group （16 patients）. The patients in the treatment group were given Cantharis Acid Sodium Vitamin B6 Injection for 5 days, while those in the control group were injected with normal saline. Double antibody sandwich ELISA was used to detect the concentration of serum vascular endothelial growth factor （s-VEGF） before and after treatment. Results Preoperative use of Cantharis Acid Sodium Vitamin B6 Injection significantly reduced the s-VEGF level in the treatment group compared to the control group （P 〈 0.05）. Conclusions Preoperative use of Cantharis Acid Sodium Vitamin B6 Injection can reduce the s-VEGF level, inhibit recurrence and metastasis of NSCLC and improve the surgery efficacy.