包覆二氧化钛固体脂质微粒的制备研究

Preparation technology of solid lipid nanoparticles for encapsulation of nano-titanium dioxide

采用界面复合物生成法制备包覆纳米TiO_2的固体脂质微粒,并对配方进行优化。分别研究了乳化剂硬脂酰谷氨酸钠与脂肪醇聚氧乙烯醚-21的复配比例、固态油脂以及液态油脂的质量分数对包覆纳米TiO_2固体脂质微粒的制备及防晒性能的影响。实验结果表明:在纳米TiO_2质量分数为3%的条件下,乳化剂总质量分数为8%,m(硬脂酰谷氨酸钠)∶m(脂肪醇聚氧乙烯醚-21)=2∶1,固态油脂二十二碳醇质量分数为4.5%,液态油脂硅油345质量分数为4.5%时,制备得到的包覆纳米TiO_2固体脂质微粒的平均粒径为219.7nm,PDI=0.221,体系稳定性较好。在纳米TiO_2质量分数不变的前提下,乳化剂复配比例和液态油脂质量分数的变化对包覆纳米TiO_2固体脂质微粒的紫外吸收性能影响较大,固态油脂质量分数的变化影响不大。

Nano-TiO2 encapsulated with solid lipid nanoparticles was prepared by interface compound generation method, and the formulation was optimized. The influences of blending ratio of emulsifiers sodium stearoyl glutamate （SG） to fatty alcohol polyoxyethylene ether-21 （S21）, as well as the mass fraction of solid lipid （docosanol） and liquid lipid （silicone oil 345） on quality and sunscreening performance of the product were studied. Results show that under conditions as： mass fraction of nano-TiO2, 3%; total mass fraction of emulsifiers, 8% （in which m（SG）：m（S21）=2：1）; mass fraction of docosanol, 4.5%; mass fraction of silicone oil 345, 4.5%; average particle size of solid lipid nanoparticles encapsulated nano-TiO2 product achieves 219.7 nm, and value of polydispersity index （PDI） achieves 0.221. The system stability of the product is quite good. Comparison of the various influencing factors shows that, for a fixed mass fraction of nano-TiO2, the blending ratio of the emulsifiers as well as mass fraction of the liquid lipid displays rather big influence on UV absorption performance of the product, while that of solid lipid is not big.