孝感市2007—2014年居民肺癌发病趋势分析

Trend in lung cancer incidence among residents in Xiaogan city,2007-2014

目的了解湖北省孝感市2007—2014年居民肺癌发病趋势,为制定肺癌防治措施提供参考依据。方法收集孝感市2007年1月1日—2014年12月31日各级医院上报的肺癌新发病案登记资料,采用发病例数、粗发病率、中国标化发病率(中标发病率)、世界标化发病率(世标发病率)、年度变化百分比(APC)等指标对肺癌的发病趋势进行统计学描述。结果孝感市2007—2014年居民肺癌粗发病率为31.01/10万~43.79/10万,年均粗发病率为34.13/10万,肺癌粗发病率随年份增长变化趋势不明显(APC=0.10,95%CI=-0.36~0.56,P>0.05);中标发病率为19.88/10万~28.08/10万,随年份增长呈上升趋势(APC=2.32,95%CI=1.60~3.04,P<0.001);世标发病率为14.14/10万~19.97/10万,随年份增长呈上升趋势(APC=2.42,95%CI=1.56~3.28,P<0.001)。2007—2014年男性和女性居民肺癌粗发病率分别为42.08/10万~58.47/10万和17.01/10万~28.34/10万,男、女性居民粗发病率随年份增长变化趋势均不明显(均P>0.05);男、女性居民肺癌中标发病率和世标发病率分别为21.78/10万~35.37/10万和23.15/10万~37.83/10万、8.39/10万~18.31/10万和7.68/10万~16.78/10万,男、女性居民中标发病率和世标发病率均随年份增长呈升高趋势(均P<0.001);居民肺癌粗发病率随年龄增长呈上升趋势(χ~2趋势=21 583.22,P<0.001),其中男性<40岁居民和女性<35岁居民肺癌粗发病率较低,男、女性居民肺癌粗发病率分别在70岁~和75岁~年龄组达高峰,随后出现一定程度降低;不同性别居民肺癌粗发病率比较,55岁~、60岁~、65岁~、70岁~、75岁~、80岁~和85岁~年龄组男性居民肺癌粗发病率均高于女性居民(均P<0.05)。结论孝感市居民肺癌中标发病率和世标发病率均随年份增长呈上升趋势,≥55岁男性居民肺癌粗发病率高于女性。

Objective To examine the trend in lung cancer （LC） incidence among residents Xiaogan city, Hubei province during the period from 2007 to 2014 and to provide evidences for developing lung cancer prevention and control measures. Methods Registration data on LC incidents between January 2007 through December 2014 among residents of Xiaogan city were collected and analyzed statistically using incidence number, crude incidence, Chinese population stand-ardized incidence （ CPSI）, world population standardized incidence （ WPSI）, and annual percentage change （APC）. Results During the period,the annual crude incidence of LC ranged from 31.01/100 000 to 43.79/100 000 for all the residents （from 42. 08/100 000 to 58. 47/100 000 for the male residents and from 17.01/100 000 to 28.34/100 000 for the female residents） ;the average annual crude incidence was 34. 13/100 000 among all the residents. No significant change trend in yearly crude incidence of LC was observed among all the residents （APC = 0. 10% ,95% confidence interval[95% CI]： -0. 36% -0. 56% ;P 〉0. 05） and among the male and the female residents （both P 〉0. 05）. The annual CPSI of LC fluctuated between 19. 88/100 000 and 28.08/100 000 for all the residents （between 21.78/100 000 and 35. 37/100 000 for the male residents and between 8.39/100 000 and 18.31/100 000 for the female residents）, with a significantly upward trend among the all residents （APC = 2. 32%, 95 % CI： 1.60% - 3.04% ; P 〈 0. 001 ） and among the male and female residents （both P 〈0. 001 ） ;the annual WPSI varied from 14. 14/100 000 to 19. 97/100 000 for all the residents （from 8.39/100 000 to 18.31/100 000 for the male residents and from 7.68/100 000 to 16. 781/100 000 for the female residents）, also with a significantly upward trend among all the residents （APC = 2.42% ,95% CI： 1.56% - 3.28% ;P 〈 0. 001 ） and among the male and female residents （both P 〈 0. 001 ）. The age specific incidence of LC increased with the increment of age among the residents （X^2trend=21583. 215, P 〈 0. 001 ）, with the lowest incidence for the male residents aged 〈 40 years and for the female residents aged 〈 35 years and the highest incidence for the male residents aged 70 - 74 years and for the female residents aged 75 - 79 years old. For the residents of 55 years old or above, the age specific incidence of LC of the males was significantly higher than that of the females across all age groups （ all P 〈 0. 05 ）. Conclusion In Xiaogan city during the period from 2007 to 2014, the Chinese and world population standardized incidence of lung cancer increased yearly among all the residents and the age specific lung cancer incidence was higher among males than among the females for the residents aged 55 years or above across all age groups.