摘要
慢性疼痛是临床治疗的难题之一,长期以来人们对慢性痛的调控研究一直集中在神经元方面。近年来的研究表明,疼痛的发生尤其是慢性疼痛不仅与神经元有关,与胶质细胞也关系密切。脊髓胶质细胞在痛觉的初级传入和整合以及痛觉调制尤其是慢性痛中枢敏化过程中具有重要作用。针刺是一种有效而副作用极少的治疗慢性痛的手段,可以通过抑制脊髓背角小胶质细胞及星形胶质细胞的活性,抑制或调节胶质细胞膜受体、细胞因子、神经营养因子、细胞内信号通路的活动,抑制神经元-胶质细胞的对话产生镇痛效应。故对脊髓胶质细胞在痛觉调制中的作用和针刺治疗慢性痛中作用机制研究进展进行了综述。
This paper explores the effects of glial cells in pain mechanisms and acupuncture in the treatment of chronic pain. Chronic pain is one of the intractable diseases in clinical practice. In the past, in revealing the underlying mechanisms of chronic pain, neurons in the peripheral and central nervous system have been focused on all along. In recent years, it has been found that the glial cells are also closely associated with the development of pain. In the present paper, the authors introduce the roles of microgliacytes and astrocytes of the spinal dorsal horns (DH) in the development of chronic inflammatory pain and neuropathie pain and their involvement in acupuncture analgesia. Experimental results indicated that when inducing pain relief, acupuncture can inhibit activation of both microglia and astrocytes in the spinal DH, and suppress neuron-microglia-astrocyte cross-talk by down-regulating pro-inflammatory cytokine levels, receptor protein expression, intracellular ERK/MAPK signaling pathway. However, the more detailed mechanisms underlying acupuncture therapy for relieving chronic pain needs being researched further.
作者
端木程琳
乔丽娜
闫娅霞
王俊英
高永辉
陈淑萍
张建梁
刘俊岭
DUANMU Cheng-lin QIAO Li-na YAN Ya-xia WANG Jun-ying GAO Yong-hui CHEN Shu-ping ZHANG Jian-liang LIU Jun-ling(Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beo'ing, 100700, China)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2017年第3期443-444,F0003,F0004,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
国家自然科学基金资助项目(81273830)-针刺对杏仁核介导的痛感觉成分和情感成分影响机制研究
(81202762)-累积电针对慢性神经痛大鼠脊髓星形胶质细胞作用的研究
(81473779)-针刺镇痛效应的小胶质细胞阿片受体竞争抑制机制
国家重点基础研究发展计划(973)计划中医专项(2013CB531904)-针药复合麻醉在甲状腺手术的应用及穴位特异性研究
(2007CB512505)-针制麻醉甲状腺手术的神经生物学机制研究