自拟益气清肠汤治疗重症溃疡性结肠炎的临床观察

Eff ect of Yiqi Qingchang Decoction on Severe Ulcerative Colitis and TCM Syndrome and Inflammatory Factors

目的观察自拟益气清肠汤对重症溃疡性结肠炎的疗效及中医证候积分和炎症因子的影响。方法将患者90例按照随机数字表法分为对照组和观察组,各45例,对照组给予美沙拉嗪肠溶片和双岐杆菌三联活菌肠溶胶囊治疗,观察组在对照组治疗基础上给予自拟益气清肠汤口服治疗。2周后观察两组患者的临床疗效和不良反应,腹泻、脓血便、腹痛、里急后重等中医证候积分,检测血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和白介素-10(IL-10)水平。结果观察组患者的有效率为93.33%,明显高于对照组75.56%(P<0.05)。观察组患者的腹泻、脓血便、腹痛、里急后重等中医证候积分均显著低于对照组(P<0.05)。观察组患者的TNF-α、IL-6均显著低于对照组,而IL-10水平高于对照组(P<0.05)。两组患者的不良反应主要为头痛、恶心、腹胀等,观察组患者的不良反应发生率24.44%(11/45)与对照组20.00%(9/45)比较,差异无统计学意义(P>0.05)。结论益气清肠汤治疗重症溃疡性结肠炎具有较好的临床疗效,可降低患者的中医证候积分,减轻炎症反应,不良反应较轻。

Objective： To explore the effect of Yiqi Qingchang decoction on severe ulcerative colitis and TCM syndrome and inflammatory factors. Methods： 90 patients were divided into the control group（45 cases） and the observation group（45 cases） according to the random number table method. The control group was given salbutamol enteric-coated tablets and Bifidobacterium triple live mushroom enteric-coated capsules,the observation group was given Yiqi Qingchang decoction on the base of the control group. The TNF-α,interleukin-6（IL-6） and interleukin-10（IL-10） were measured. The clinical efficacy and adverse reactions,the TCM syndromes such as diarrhea,bloody purulent stool,stomachache,tenesmus,the serum levels of TNF-α,IL-6 and IL-10 were measured before and after 2 weeks of treatment. Results： The effective rate was 93.33% in the observation group,which was higher than 75.56% in the control group（P〈0.05）. The scores of TCM syndromes such as diarrhea,bloody purulent stool,stomachache,tenesmus in the observation group were significantly lower than those in the control group（P〈0.05）. The levels of TNF-α and IL-6 in the observation group were significantly lower than those in the control group,while the IL-10 level was higher than that in the control group（P〈0.05）. There were no significant differences in the incidence of adverse reactions between the two groups（24.44% in the observation group and 20.00% in the control group）（P〈0.05）. The adverse effects of the two groups were headache,nausea and bloating. Conclusion： Yiqi Qingchang decoction has good clinical effect in the treatment of severe ulcerative colitis,which can reduce the TCM syndromes and the inflammatory reaction with mild adverse reaction.