主要革兰阳性球菌变化趋势及对抗菌药物敏感率分析

Antimicrobial resistance trends and analysis of antimicrobial drug sensitivity rate from important Gram-positive cocci isolated

目的监测医院革兰阳性球菌的变化趋势及对抗菌药物敏感性的变化,以指导临床抗菌药物治疗的优化。方法收集2013年1月—2015年12月聊城市第二人民医院1 764例非重复革兰阳性球菌,应用肉汤稀释法测定最小抑菌浓度(MIC),比较主要革兰阳性球菌不同年份之间的感染发生率和药物敏感率。结果2013年1月—2015年12月金黄色葡萄球菌、凝固酶阴性葡萄球菌感染率有下降趋势,而肺炎链球菌感染率呈明显上升趋势。结论持续监测医院革兰阳性球菌的变化趋势及对抗菌药物敏感性的变化,有助于对感染患者合理应用抗菌药物。

Objective To investigate antimicrobial resistance trends and drug sensitivity rate from important gram-positive cocci. Methods Retrospective study.From January 2013 to December 2015,1 764 consecutive and nonrepetitive gram-positive cocci were collected from the People＇s Second Hospital of liaocheng.The minimal inhibitory concentration （MIC） of antibacterial agents was determined by broth dilution method. The prevalence of important gram-positive cocci between every year and adult patients and antimicrobial drug sensitivity rates were compared using chi-square test. Results From 2013 and 2015,the prevalence of Staphylococcus aureus and coagulase-negative staphylococci has decreased, but the prevalence of Streptococcus pneumoniae was decreased. Conclusions Continuous surveillance is warranted to evaluate the resistance trend and antimicrobial drug sensitivity rate of clinically important Gram-positive cocci.