预防性宫体注射卡前列素氨丁三醇在重度妊娠期肝内胆汁淤积症孕妇剖宫产中的应用效果

Application effect of prevention of uterine body injection of Carboprost Tromethamine in patients with Severe intrahepatic cholestasis of Pregnancy

目的通观察重度妊娠期肝内胆汁淤积症患者剖宫产术中预防性使用卡前列素氨丁三醇宫体部注射的临床效果。方法将44例重度妊娠期肝内胆汁淤积症行剖宫产产妇根据住院号随机分为观察组和对照组,对照组剖宫产过程中胎儿娩出后宫体部常规注射缩宫素20 U,观察组则采用注射缩宫素20 U及卡前列素氨丁三醇250μg,比较2组产时、产后24 h出血情况。结果观察组产时、产后24 h出血量均明显少于对照组,具有显著统计学差异(P<0.01),2组手术时间无明显差别(P>0.05)。结论预防性宫体部注射卡前列素氨丁三醇在重度妊娠期肝内胆汁淤积症患者剖宫产中应用可获得良好的效果。

Objective To observe the clinical effect of the prophylactic use of theCarboprost Tromethamine in the treatment of intrahepatic cholestasis of pregnancy in patients with severe pregnancy induced by cesarean section. Methods 44 cases of severe intrahepatic cholestasis of pregnancy in cesarean section were according to the hospital, were randomly divided into observation group and control group, control group of cesarean section during fetal childbirth uterine routine injection of oxytocin 20 units,while the observation group with injection of 20 units of oxytocin and Carboprost Tromethamine 250 μg, compared with two groups of intrapartum and postpartum hemorrhage 24 hours. Results Group Observation of 24 postpartum hemorrhage hours was significantly less the than group control with, statistical significance （P〈0.01）,was no there significant difference in operation time （P〉0.05）.Conclusion the application of the preventive effect of the injection of the Carboprost Tromethamine in the cesarean section in patients with severe intrahepatic cholestasis of pregnancy can get good results.