外周动静脉同步换血治疗新生儿重症高胆红素血症效果评价

Evaluation of the effect of peripheral arteriovenous simultaneous exchange transfusion on neonatal severe hyperbilirubinemia

目的:探讨外周动静脉同步换血治疗新生儿重症高胆红素血症的临床效果。方法:对40例符合同步换血疗法的新生儿重症高胆红素血症患儿进行外周动静脉同步换血疗法,比较治疗前后患儿的血清胆红素、生理生化指标、并发症等。结果:治疗后的直接胆红素、间接胆红素及总胆红素均明显低于治疗前(P<0.05);治疗后的白细胞、血小板均明显低于治疗前(P<0.05),而治疗后的血红蛋白、血糖则明显高于治疗前(P<0.05);换血过程中出现8例并发症(20.0%),经过治疗后并发症得到有效控制。结论:重症高胆红素血症患儿实施同步换血疗法后,可有效清除血清胆红素,具有操作简便、安全、有效等优点,值得在临床推广应用。

[Objective] To explore the clinical the effect of peripheral arteriovenous simultaneous exchange transfusion on neonatal severe hyperbilirubinemia. [Method]40 cases of severe hyperbilirubinemia of neonate were chosen to treated with peripheral arteriovenous synchronous exchange transfusion. Then,the indexes of serum bilirubin,physiologial and biochemical indicators were compared before treatment and after treatment. [Result]The levels of direct bilirubin,indirect bilirubin and total bilirubin after treatment were much lower than before treatment（ P〈0. 05）. The levels of white blood cell and platelet after treatment were much lower thanbefore treatment（ P〈0. 05）,but the levels of hemoglobin and blood sugar after treatment were much higher than before treatment（ P〈0. 05）. There were 8 cases（ 20. 0%） happening complications,and the complications were controlled after treatment. [Conclusion]Severe hyperbilirubinemia of neonate carrying out synchronous exchange transfusion,it could effectively remove serum bilirubin. This method has these good qualities such as conveniently operating,safe,effective and less complications,so it deserves to spread in clinic.