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额颞叶梗死患者血浆中SS和Ach在VD发病中的作用 被引量:1

The role of plasma somatostatin and acetylcholine in vascular dementia among frontal lobe and temporal lobe's infarction
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摘要 目的探讨脑不同部位梗死后血管性痴呆(VD)患者血浆生长抑素(SS)和乙酰胆碱(Ach)含量差异及其与痴呆程度的关系。方法选择VD患者43例为观察组,脑梗死而非痴呆的患者37例为对照组。采用放射免疫法测量血浆中SS和Ach的含量,用简易精神状态量表(MMSE)评定其认知功能,比较2组患者入院后第2天血浆SS和Ach的水平。结果观察组血浆SS和Ach含量明显低于对照组,差异有统计学意义(P<0.05);额颞叶梗死患者血浆SS和Ach含量较其他部位梗死含量低,差异有统计学意义(P<0.05);痴呆程度越重,血浆SS和Ach含量下降越明显,差异有统计学意义(P<0.05)。结论 VD患者中脑不同部位梗死血浆SS和Ach含量不同,以额颞叶下降最为明显,且与痴呆程度呈负相关性,血浆中SS和Ach可能作为早期诊断VD的生物学指标之一。 Objective To explore the change of plasma somatostatin and acetylcholine in vascular dementia among different infarction, especially in the frontal lobe and the temporal lobe, and to find the relationship between them. Methods Accoding to the diagnostic criteria for vascular dementia,43 patients were collected as the VD group. 37 infarction patients without dementia were the control group. The radioimmunoassay to detect the somatostatin(SS) and acetylcholine(Ach) in plasma were used. Mini - mental state examination(MMSE)was used to score their cognitive function. Results The SS and Ach concentrations in vascular dementia were found to be significantly lower than those controls (P 〈 0.05). The SS and Ach concentrations in frontal lobe and temporal lobe were lower than the other sites (P 〈 0.05). The more severe of dementia, the lower of SS and Ach in plasma. Conclusions Different sites of infarction have different concentrations of SS and Ach in VD, especially the frontal lobe and temporal lobe. The depression of SS and Ach is correlated with the cognitive impairment. The SS and Ach in plasma might be used as the biochemical markers of VD in the early stage.
出处 《宁夏医学杂志》 CAS 2017年第4期312-314,共3页 Ningxia Medical Journal
基金 宁夏自然科学基金资助项目(NZ14173)
关键词 血管性痴呆 额叶脑梗死 颞叶脑梗死 生长抑素 乙酰胆碱 Vascular dementia Frontal lobe infarction Temporal lobe infarction Somatostatin Acetylcholine
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