臭氧自血疗法辅助治疗男性原发性高血压病的疗效和安全性研究

Efficacy and Safety of Ozoned Autohemotherapy in Adjuvant Therapy of Men with Primary Hypertension

目的观察评估臭氧自血疗法(O3-AHT)辅助治疗男性原发性高血压病的疗效和安全性。方法选取2014年1月—2015年1月在首都医科大学宣武医院就诊的男性原发性高血压病患者60例,采用随机数字表法分为试验组和对照组,各30例。对照组给予口服左旋氨氯地平,5 mg/次,1次/d。试验组在对照组基础上,给予O3-AHT(浓度为20 mg/L、1次/2 d、10次/疗程)辅助治疗。记录治疗前(T0)、首次疗程结束后3个月(T1)、二次疗程结束后3个月(T2)、三次疗程结束后3个月(T3)的收缩压(SBP)和心率(HR);记录T3的药物口服情况和满意度指数(PSI)评分等级;记录治疗期间不良反应发生情况。结果两组年龄、病程间差异无统计学意义(P>0.05)。两组SBP间差异有统计学意义(P<0.05),不同时间点SBP间差异有统计学意义(P<0.05),治疗方法和时间在SBP上存在交互作用(P<0.05)。两组HR间差异无统计学意义(P>0.05),不同时间点HR间差异无统计学意义(P>0.05);治疗方法和时间在HR上不存在交互作用(P>0.05)。试验组药物口服情况和PSI评分等级均优于对照组,差异有统计学意义(P<0.05)。两组患者均无一例出现严重低血压、心脑血管意外、溶血、过敏等不良反应。结论O3-AHT辅助治疗男性原发性高血压病的疗效确切,安全性高。

Objective To evaluate the efficacy and safety of ozoned autohemotherapy （O 3-AHT）in adjuvant therapy of men with primary hypertension. Methods Sixty male patients with primary hypertension treated at Xuanwu Hospital Capital Medical University from January 2014 to January 2015 were randomly divided into experiment group and control group by random number table method,each group had 30 cases. The control group orally took levamlodipine at a dose of 5 mg,once per day. Based on that of the control group,adjuvant therapy of O 3-AHT （concentration：20 mg/ L,once per two days,ten times a course of treatment courses）was given to the experiment group. The systolic blood pressure （SBP）and heart rate （HR）before treatment （T 0 ）,3 months after the first course of treatment （T 1 ）,3 months after the second course of treatment （T 2 ）,3 months after the third course of treatment （T 3 ）were recorded;the oral status and grades of satisfaction index （PSI）scores of T 3 were recorded. The incidence of adverse events during the treatment was recorded. Results There was no significant difference in age and course of disease （P 〉 0. 05）. There was significant difference in SBP between two groups （P 〈 0. 05）. There was significant difference in SBP at different time points （P 〈 0. 05）. The treatment method and time had interactive effects on SBP （P 〈 0. 05）. There was no significant difference in HR between two groups （P 〉 0. 05）,there was no significant difference in HR at different time points （P 〉 0. 05）. The treatment method and time had no interactive effects on HR （P 〉 0. 05）. The status of taking medicine orally and grades of PSI scores of the experiment group were significantly better than those of the control group （P 〈 0. 05）. None of the patients in the two groups had severe hypotension,cardiovascular and cerebrovascular accident, hemolysis,allergies and other adverse reactions. Conclusion O 3-AHT shows obvious curative effect and high safety in adjuvant therapy of men with primary hypertension.