利咽饮雾化吸入治疗小儿急性咽喉炎的疗效及对炎性因子的影响

Efficacy of Liyan Decoction Atomizing Inhalation in Treating Acute Pharyngitis and Its Influence on Inflammatory Factors

目的观察利咽饮雾化吸入治疗小儿急性咽喉炎的疗效及对炎性因子的影响。方法采用随机数字表法将2014年3月至2015年3月收治的100例急性咽喉炎患儿分为观察组和对照组,各50例。两组患儿均予抗感染、抗病毒、补液对症治疗,在此基础上,对照组患儿饭后给予小儿咽扁冲剂口服,4~8 g/次,3次/日;观察组患儿采用医院自制的利咽饮雾化液雾化吸入治疗,每次40 m L,1次10 min,2次/日。比较两组患儿的临床症状缓解时间、临床疗效差异、炎性因子改善情况,记录治疗期间两组不良反应的发生情况。结果观察组患儿总有效率为96.00%,明显高于对照组的82.00%(P<0.05);治疗后,观察组患儿的咽痛、异物感、咳痰、咽部红肿、体温恢复时间均显著短于对照组患儿(P<0.05);观察组患儿肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)水平明显低于对照组患儿(P<0.05);两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论利咽饮雾化吸入对小儿咽喉炎患儿临床疗效较好,可使患儿临床症状及体征得到恢复,炎性因子水平明显改善,且无明显不良反应,安全性较高,值得临床推广,但该药能否长期使用,仍有待进一步研究。

Objective To investigate the clinical efficacy of Liyan Decoction Inhalation in treating acute pharyngitis and its influence on inflammatory factors. Methods 100 cases of throat acute inflammation in children in the hospital from March 2014 to March 2015 were selected and divided into the observation group and the control group according to the random number table method,50 cases in each group. The control group was treated by pediatric pharyngeal flat granule 4-8 g/time,3 times/d after oral administration treat-ment;the observation group was treated with nebulized inhalation of Liyan Decoction,40 mL/time,10 min/time,2 times/d. The clinical symptom relief time,the clinical curative effect difference,the improvement of inflammatory factors were compared between the two groups,and the incidence rates of the adverse reactions in the two groups were recorded. Results The total effective rate of the obser-vation group was 96. 00%,which was significantly higher than 82. 00% in the control group（ P 〈 0. 05）. After treatment,the recovery time of sore throat,foreign body sensation,expectoration,pharyngeal swelling and temperature in the observation group were significantly shorter than those in the control group（ P 〈 0. 05）;the levels of TNF-α and IL-6 were also significantly lower than those in the control group（ P 〈 0. 05）. There was no significant difference between the two groups in the incidence rates of adverse reactions（ P 〉 0. 05）. Conclusion Liyan Decoction inhalation in treating children with pharyngitis has better clinical efficacy,can make children with clinical symptoms and signs recovery faster and significantly improve inflammatory factors with no significant adverse reactions and high safety, whici is worthy of clinical promotion. But whether the drug can be used in the long term still remains to be further studied.