泌尿系感染患者沙眼衣原体与淋病奈瑟菌和解脲脲原体感染及耐药状况调查

Investigation of Chlamydia trachomatis,Neisseria gonorrhoeae and Ureaplasma urealyticuminfection and drug resistance in patients with urinary tract infection

目的探讨泌尿系感染患者沙眼衣原体(Ct)、淋病奈瑟菌(Ng)、解脲脲原体(Uu)感染及耐药情况,为泌尿系感染的临床诊断及治疗提供参考。方法选取2015年6月-2016年6月医院就诊的泌尿系感染的患者200例,采集尿道分泌物以实时荧光定量聚合酶链反应检测Ct、Ng、Uu感染状况,药敏试验采用纸片法。结果 65例检出Ct、Ng、Uu感染,感染率为32.50%;病原体单一感染者42例、混合感染者23例,分别占64.62%、35.38%;Ct对红霉素、甲砜霉素、罗红霉素耐药率分别为80.00%、60.00%、43.33%,Ng对甲砜霉素、阿奇霉素、罗红霉素耐药率分别为65.00%、55.00%、45.00%,Uu对甲砜霉素、红霉素、罗红霉素耐药率分别为60.98%、58.54%、53.66%。结论泌尿系感染患者Ct、Ng、Uu感染率高,主要以单一病原体感染多见,部分患者可合并多种病原体感染,Ct、Ng、Uu对临床常用的抗菌药物耐药性不同。

OBJECTIVE To discuss Chlamydia trachomatis（Ct）,Neisseria gonorrhoeae（Ng）and Ureaplasma urealyticum（Uu）infection and drug resistance in patients with urinary tract infection,so as to provide references for clinical diagnosis and treatment of urinary tract infection.METHODS A total of 200 cases of patients with urinary tract infection from Jun.2015 to Jun.2016 were selected.The urethral secretions of patients were collected,and the Ct,Ng and Uu infection was detected by real time fluorescence quantitative polymerase chain reaction.The drug sensitive test was using paper method.RESULTS Totally 65 cases of Ct,Ng and Uu infection were detected,and the infection rate was 32.50%.There were 42 cases of single pathogen infection and 23 cases of mixed infection,accounting for 64.62% and 35.38%,respectively.The resistant rates of Ct to erythromycin,thiamphenicol and roxithromycin were 80.00%,60.00% and 43.33%,respectively,the resistant rates of Ng to thiamphenicol,azithromycin and roxithromycin were 65.00%,55.00% and 45.00%,respectively,and the resistant rates of Uu to thiamphenicol,erythromycin and roxithromycin were 60.98%,58.54% and 53.66%,respectively.CONCLUSIONCt,Ng and Uu infection rates are high in patients with urinary tract infection,which are mainly infected by single pathogen,and some are infected by multiple pathogens.The drug resistant rates of Ct,Ng and Uu to clinical commonly used antibiotics are different.