甲状腺功能亢进对住院患者医院感染率的影响及干预措施研究

Effect of hyperthyroidism on nosocomial infection rate of patients and intervention measures

目的研究甲状腺功能亢进对住院患者医院感染发生情况的影响并探讨干预措施,为临床治疗提供参考依据。方法选取2012-2015年医院收治的215例甲亢患者为研究对象,配对选取同一时期的住院患者215例为对照组,比较两组患者的临床资料及院内感染率,并分析甲亢患者出现感染的危险因素。结果甲亢患者及对照组患者性别、年龄、并发症、BMI、血压、LVEF、血常规及血生化检查结果比较,差异无统计学意义;甲亢组22例患者出现感染,感染率10.23%;对照组7例患者发生感染,感染率3.26%,差异有统计学意义(P<0.05);合并心脏病、重型甲亢、LVEF≤45%、白细胞<4×10~9/L是发生感染的独立危险因素(P<0.05)。结论甲亢患者医院感染的发生率较高,且与多种因素有关,临床上应该采取综合措施全面干预。

OBJECTIVE To study the effect of hyperthyroidism on nosocomial infections of patients and the inter- vention measures, so as to provide references for clinical treatment. METHODS From Jan. 2012 to Dec. 2015, 215 patients with hyperthyroidism were chosen as study objects, and 215 patients without hyperthyroidism were cho- sen as control group. The clinical data and nosocomial infection rate were compared between the two groups, and the risk factors of infection in patients with hyperthyroidism were analyzed. RESULTS The gender, age, complica- tions, BMI, blood pressure, LVEF, results of blood routine and blood biochemistry had no significant difference between the two groups. The nosocomial infection rate of hyperthyroidism patients was 10.23 % （22/215）, that of control group was 3.26 % （7/215）, and the difference had significance（P〈0.05）. Heart disease, severe hyperthy- roidism, LVEF≤ 45%, and WBC 〈 4× 109/L were independent risk factors for infections （P 〈 0. 05）. CONCLUSION Patients with hyperthyroidism are vulnerable to nosocomlal infections, which is related to multiple factors, and thus requires comprehensive intervention measures in clinic.