黑地黄丸调节脂质代谢紊乱改善慢性肾衰竭患者“微炎症状态”干预机制研究

Intervention Mechanism Research of Heidihuang Pill Regulating Lipid Metabolic Disorder and Improving“Micro Inflammation Status”in Patients with CRF

目的:研究黑地黄丸对慢性肾衰竭(CRF)患者脂质代谢的影响及对"微炎症状态"的改善作用,揭示其调节机制。方法:随机化设黑地黄丸组和尿毒清组,每组30例,分别予黑地黄丸、尿毒清颗粒干预,同等条件下空腹抽取静脉血,检测患者总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平。结果:黑地黄丸组治疗后患者血中TC水平(P<0.05)、TG水平(P<0.01)、LDL水平(P<0.01)明显降低,同时HDL水平显著升高(P<0.01),且IL-6、TNF-α、CRP含量显著降低(P<0.01)。结论:黑地黄丸可通过调节脂质代谢紊乱,改善CRF"微炎症状态",保护患者肾功能。

Objective：To study the Heidihuang Pill in patients with chronic renal failure（CRF）and the effect of lipid metabolism and effect on the improvement of the＂micro inflammation status＂,to reveal the regulating mechanism. Methods：Randomized set black pill group and uric poisonous clear group,each group of 30 people,respectively to the black pill,uric poisonous clear particles and intervention,fasting venous blood was drawn under the same working conditions,detection of patients with TC,TG,HDL,LDL and CRP level,TNF-α,IL-6. Results：Heidihuang Pill group patients serum TC level after treatment（P〈0.05）,TG（P〈0.01）,and LDL levels（P〈0.01）significantly decreased,while the marked increase in HDL levels（P〈0.01）,and IL-6,TNF-α,CRP levels decreased significantly（P〈0.01）. Conclusion：Heidihuang Pill through regulating lipid metabolism disorder,to improve CRF＂micro inflammation status＂,protect the patients＇ kidney function.