胱硫醚β-合成酶基因多态性与牡丹江地区汉族朝鲜族原发性高血压的相关性

Correlation between CBS 844ins68 polymorphism and essential hypertension in Han nationality、korean nationality in Mudanjiang region

目的探讨胱硫醚β-合成酶(CBS 844ins68)基因多态性与牡丹江地区汉族朝鲜族原发性高血压的相关性研究。方法运用PCR的方法检测牡丹江地区汉族高血压患者107人,汉族正常对照组101人,朝鲜族高血压患者105人,朝鲜族正常对照组96人的血浆Hcy水平及其CBS 844ins68基因型,并进行测序验证。结果未发现CBS 844ins68基因杂合突变型和纯合突变型。结论 CBS 844ins68多态性与本地区汉族、朝鲜族原发性高血压的发生无相关性。

Objective To study the relationship between CBS 844ins68 gene polymorphism and essential hypertension in Korean and Han group in Mudanjiang Prefecture. Methods The study was performed in 107 Han patients and 105 Korean patients with essential hypertensive, and was performed in 101 Han peoples and 96 Korean peoples with normatension. CBS 844ins68 genetypes were detected by polymerase chain reaction and gene sequencing. Results Heterozygous mutation genetypes or homozygous mutant genetypes were not found in CBS 844ins68 gene polymorphism. Conclusion Ther were no relationship between CBS 844ins68 gene polymorphism and essential hypertension in Korean and Han group in Mudanjiang Prefecture.