CT引导下^(125)I粒子植入治疗恶性肿瘤的临床研究

Clinical research of CT-guided ^(125)I seed implantation in the treatment of malignant tumor

目的:探讨^(125)I粒子植入治疗恶性肿瘤的可行性、临床疗效及影响因素。方法 :回顾性分析我院自2013年4月—2016年3月行CT引导下^(125)I粒子植入治疗的38例恶性肿瘤患者的资料,比较术前与术后2月、6月肿瘤体积变化情况,根据肿瘤体积变化、血供变化或肿瘤代谢变化对疗效进行分级(CR:完全缓解;PR:部分缓解;SD:肿瘤稳定;PD:恶化;CR+PR:总有效率),并评价其短期疗效。采用SPSS 17.0统计学软件对术前术后肿瘤体积变化进行配对t检验,P<0.05为差异有统计学意义。结果:术后2月:CR 3例,PR 18例,SD 15例,PD 2例,CR+PR为55.26%;术后6月:CR 6例,PR 21例,SD 9例,PD 2例,CR+PR为71.05%。术前肿瘤体积与术后2月、术后6月肿瘤体积比较差异有统计学意义(P<0.05)。结论:^(125)I粒子植入治疗恶性肿瘤创伤小,不良反应轻,安全可行,在控制肿瘤生长、缓解患者的临床症状方面,取得了较为满意的近期疗效。

Objective： To investigate the feasibility, clinical efficacy and influencing factors of 125I particles in the treatment of malignant tumors. Methods： The clinical data of 38 patients with malignant tumors treated by CT-guided 125I seed therapy in our hospital from April 2013 to March 2016 were retrospectively analyzed. The preoperative and postoperative tumor volume changes of 2 months and 6 months were compared. According to the changes of tumor volume, blood supply or tumor metabolic changes, the curative effect was graded（CR： complete remission, PR： partial remission, SD： tumor stability, PD： progression of disease, CR＋PR for the total effective rate）, and its short-term curative effect was evaluated. The data were analyzed by SPSS 17.0 statistical software before and after operation. The t test was used for statistical analysis. The difference of P〈0.05 was statistically significant. Results： Postoperative 2 months, CR： 3 cases, PR： 18 cases, SD： 15 cases, PD： 2 cases, CR＋PR： 55.26%; 6 months after operation, CR： 6 cases, PR： 21 cases, SD： 9 cases, PD： 2 cases; CR＋PR： 71.05%. There was a significant difference in tumor volume at preoperative and postoperative 2 and 6 months（P〈0.05）. Conclusion： 125I seed implantation is a safe and effective method for the treatment of malignant tumor with less trauma, less adverse reaction, and satisfactory clinical efficacy in the control of tumor growth and the clinical symptoms of patients.