电热针治疗强直性脊柱炎疗效观察及对IL-1、IL-6的影响

Observations on the Therapeutic Effect of Electrothermal Acupuncture on Ankylosing Spondylitis and Its Impact on IL-1 and IL-6

目的观察电热针治疗强直性脊柱炎的临床疗效。方法将60例患者随机分成治疗组和对照组,每组30例,治疗组用电热针治疗,对照组用甲氨蝶呤联合柳氮磺吡啶,观察患者治疗前,治疗4星期后,治疗8星期后扩胸度、骶髂关节压痛度、关节压痛个数、晨僵时间,Schober试验在不同时间点得分情况及白细胞介素1(IL-1)、白细胞介素(IL-6)含量变化。结果在治疗4星期后、治疗8星期后,治疗组扩胸度、骶髂关节压痛度、关节压痛个数、晨僵时间、Schober试验与治疗前比较差异有统计学意义(P<0.05);两组治疗后IL-1、IL-6含量与治疗前比较差异有统计学意义(P<0.05);治疗组总有效率为80.0%,对照组总有效率73.3%,组间比较差异无明显统计学意义(P>0.05)。结论电热针治疗强直性脊柱炎疗效显著,且安全性高;电热针治疗强直性脊柱炎的机制可能与其能调节体内IL-1及IL-6水平有关。

Objective To investigate the clinical efficacy of electrothermal acupuncture in treating ankylosing spondylitis.Method Sixty patients were randomly allocated to treatment and controlgroups, 30 cases each.The treatment group received electrothermal acupuncture and the control group took methotrexate plus sulfasalazine.The extent of chestexpansion, the severity of sacroiliac joint tenderness, the number of tender joints and morning stiffness time were examined,Schober＇s testscores at different time points were recorded and interleukin-1 （IL-1） and interleukin-6 （IL-6） contents were measured before and after 4 and 8 weeks of treatment.Result In the treatment group, there were statistically significant differences in the extent of chestexpansion, the severity of sacroiliacjoint tenderness, the number of tender joints, morning stiffness time andSchober＇s testscores after 4 and 8 weeks of treatment compared with before treatment （P〈0.05）.There were statistically significant pre-/post-treatment differences in IL-1 and IL-6 contents in the two groups （P〈0.05）. The total efficacy rate was 80.0% in the treatment group and 73.3% in the control group; there was no statistically significant difference between the twogroups（P〉0.05）. ConclusionElectrothermal acupuncture has a marked therapeutic effect onankylosing spondylitisand is of high safety.The mechanism of electrothermal acupuncture treatment forankylosing spondylitismay be related to its regulating IL-1 and IL-6 levels in the body.