祛风止动方对抽动障碍患儿外周血调节性T细胞的影响

The Effect of Qufeng Zhidong Decoction (祛风止动方) on Regulatory T cells in Peripheral Blood of Child Patients with Tic Disorder

目的探讨祛风止动方对抽动障碍患儿调节性T细胞(Treg)外周血表达水平的影响。方法收集抽动障碍患儿30例为治疗组,另选取健康儿童20例为对照组。治疗组给予祛风止动方每日1剂,疗程3个月。于治疗组治疗前后及对照组入组时检测受试者外周血Treg表达。结果治疗前治疗组儿童外周血Treg表达水平显著低于对照组,在学龄前(3~6岁)和学龄期(7~16岁)治疗组外周血Treg表达水平亦较对照组降低(P<0.01)。治疗组学龄前和学龄期患儿治疗后外周血Treg表达水平均较治疗前出现上升趋势,但差异无统计学意义(P>0.05)。结论 Treg表达水平异常与抽动障碍发病有关,祛风止动方对抽动障碍患儿外周血Treg表达有上调作用。

Objective To explore the effect of Qufeng Zhidong Decoction（ 祛风止动方） on expression level of regulatory T cells（ Treg） in peripheral blood of child patients with tic disorder. Methods Thirty children patients with tic disorder were collected as the treatment group. Another 20 healthy children were selected as the control group. The treatment group was given Qufeng Zhidong Decoction granules 1 dose per day for 3 months. The expression of Treg in peripheral blood of subjects was tested before and after treatment in the treatment group,and at the time when entered group in the control group. Results Before treatment,the expression level of Treg in peripheral blood of children in the treatment group was remarkably lower than that in the control group. At their preschool period（ 3 ~6 years old） and school age（ 7 ~ 16 years old）,the expression level of Treg in peripheral blood in the treatment group also decreased compared with the control group（ P 〈0. 01）. After treatment The expression level of Treg in peripheral blood of child patients in the treatment group at their preschool period and school age all showed rising trend compared with that before treatment,but there was no statistical significance in differences（ P〉 0. 05）. Conclusion Abnormal expression of Treg is related to the attack of tic disorder. Qufeng Zhidong Decoction has up-regulation effect on Treg expression of child patients with tic disorder.