慢性糜烂性胃炎HGF、c-Met相关性研究

Correlation Research on HGF and c-Met of Chronic Erosive Gastritis Patients

目的观察慢性糜烂性胃炎患者血清及胃黏膜组织肝细胞生长因子(hepatocyte growth factor,HGF)及HGF受体(c-Met)相关性。方法选择70例慢性糜烂性胃炎患者,分为浊毒内蕴证和肝胃不和证组,检测两组血清HGF表达水平及胃黏膜组织HGF、c-Met表达水平。分析胃黏膜组织HGF、c-Met相关性及血清和胃黏膜组织HGF相关性。结果浊毒内蕴组HGF、c-Met表达水平明显高于肝胃不和组(P<0.05);胃黏膜组织中HGF和c-Met的表达呈正相关(r=0.831,P<0.05);血清HGF水平和胃黏膜组织中HGF的表达呈正相关(r=0.656,P<0.05)。结论慢性糜烂性胃炎浊毒内蕴证与HGF、c-Met存在相关性。

Objective To observe the correlation of hepatocyte growth factor （HGF）and Hepato- cyte growth factor receptor （c-Met） in serum and gastric mucosa tissues of chronic erosive gastritis pa- tients. Methods Totally 70 patients with chronic erosive gastritis were selected and assigned to turbidity toxin intrinsic syndrome group and Gan-wei disharmony syndrome group, HGF expression level of ser- um,and HGF,c-Met expression level of gastric mucosa tissues were measured;the correlation of HGF and c-Met in gastric mucosa tissues, and the correlation of HGF in serum and gastric mucosa tissues were analyzed. Results The expression level of HGF and c-Met in turbidity toxin intrinsic syndrome group was higher than that in Gan-wei disharmony syndrome group（P 〈0.05）; the expression level of HGF in gastric mucosa tissues was positively correlated with c-Met（r =0.831, P 〈0.05） ; the expression level of HGF in serum was positively correlated with that of gastric mucosa tissues（r =0.656, P 〈0.05）. Conclusions There was correlation between turbidity toxin intrinsic syndrome of Chronic Erosive Gastri- tis patients and the expression level of HGF and c-Met,