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慢性糜烂性胃炎HGF、c-Met相关性研究 被引量:16

Correlation Research on HGF and c-Met of Chronic Erosive Gastritis Patients
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摘要 目的观察慢性糜烂性胃炎患者血清及胃黏膜组织肝细胞生长因子(hepatocyte growth factor,HGF)及HGF受体(c-Met)相关性。方法选择70例慢性糜烂性胃炎患者,分为浊毒内蕴证和肝胃不和证组,检测两组血清HGF表达水平及胃黏膜组织HGF、c-Met表达水平。分析胃黏膜组织HGF、c-Met相关性及血清和胃黏膜组织HGF相关性。结果浊毒内蕴组HGF、c-Met表达水平明显高于肝胃不和组(P<0.05);胃黏膜组织中HGF和c-Met的表达呈正相关(r=0.831,P<0.05);血清HGF水平和胃黏膜组织中HGF的表达呈正相关(r=0.656,P<0.05)。结论慢性糜烂性胃炎浊毒内蕴证与HGF、c-Met存在相关性。 Objective To observe the correlation of hepatocyte growth factor (HGF)and Hepato- cyte growth factor receptor (c-Met) in serum and gastric mucosa tissues of chronic erosive gastritis pa- tients. Methods Totally 70 patients with chronic erosive gastritis were selected and assigned to turbidity toxin intrinsic syndrome group and Gan-wei disharmony syndrome group, HGF expression level of ser- um,and HGF,c-Met expression level of gastric mucosa tissues were measured;the correlation of HGF and c-Met in gastric mucosa tissues, and the correlation of HGF in serum and gastric mucosa tissues were analyzed. Results The expression level of HGF and c-Met in turbidity toxin intrinsic syndrome group was higher than that in Gan-wei disharmony syndrome group(P 〈0.05); the expression level of HGF in gastric mucosa tissues was positively correlated with c-Met(r =0.831, P 〈0.05) ; the expression level of HGF in serum was positively correlated with that of gastric mucosa tissues(r =0.656, P 〈0.05). Conclusions There was correlation between turbidity toxin intrinsic syndrome of Chronic Erosive Gastri- tis patients and the expression level of HGF and c-Met,
出处 《中国中西医结合杂志》 CAS CSCD 北大核心 2017年第4期410-413,共4页 Chinese Journal of Integrated Traditional and Western Medicine
基金 河北省科学技术研究与发展计划(No.10276103D)
关键词 慢性糜烂性胃炎 浊毒内蕴证 肝细胞生长因子 肝细胞生长因子受体 chronic erosive gastritis turbidity toxin intrinsic syndrome hepatocyte growth factor recepter of Hepatocyte growth factor
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