益气养阴活血法对糖尿病肾病患者血液流变学的影响

The Influence of Method of Boosting Qi and Nourishing Yin and Promoting Blood Circulation on Hemorheology of Diabetic Nephropathy

目的:观察益气养阴活血法对糖尿病肾病患者血液流变学的影响。方法:选择本院2015年1月—2016年1月就诊的糖尿病肾病患者72例,随机分为对照组和观察组,每组各36例。对照组给予厄贝沙坦治疗,观察组以益气养阴为治疗大法,给予自拟中药方剂治疗。观察两组患者治疗前后血液流变学指标变化情况及肾功能[血尿素氮(blood urea nitrogen,BUN)、肌酐(serum creatinine,SCR)、尿白蛋白排泄率(urinary albumin excretion rates,UAER)及24 h尿微量白蛋白(uric micro-albumin in 24 h,24h UMA)]相关指标。结果:两组患者治疗后血液流变学指标改善情况优于治疗前,且观察组优于对照组,差异均有统计学意义(P<0.05)。观察组治疗后BUN、UAER、Scr及24h UMA低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论:益气养阴活血法可有效改善糖尿病肾病患者血液高凝状态,从而促进微循环的改善,减少肾损害,延缓病情的进展。

Objective： To observe the influence of method of boosting qi and nourishing yin and promoting blood circulation on hemorheology of diabetic nephropathy. Methods： Seventy-two patients with diabetic nephropathy who were treated in our hospital between Jan. of 2015 and Jan. of 2016 were chosen as the research subjects,and randomly divided into the control group and the observation group,with 36 cases in each group. The ones in the control group were treated with Irbesartan,while the ones in the observation group adopted method of boosting qi and nourishing yin and promoting blood circulation and were treated with self-designed TCM formula. Then the two groups＇ changes of hemorheology indexes before and after the treatment,blood urea nitrogen（ BUN）,serum creatinine（ SCR）,urinary albumin excretion rates（ UAER） and uric micro-albumin in 24 h（ 24 h UMA） and other related indexes were observed. Results： After the treatment,the two groups＇ improvement of hemorheology index was better than before the treatment; And the observation group was better than the control group,the difference was statistically significant（ P〈0. 05）. The BUN,UAER,Scr and 24 h UMA in the observation group were lower than those before treatment; the observation group was lower than that in the control group,and all the differences were statistically significant（ P〈0. 05）. Conclusion： Method of boosting qi and nourishing yin and promoting blood circulation can effectively improve the hypercoagulable state in patients with diabetic nephropathy,thereby promoting the improvement of microcirculation,reducing renal damage,and delaying the progress of the disease.