脉络宁口服液联合甲钴胺片治疗老年糖尿病周围神经病变的疗效

Curative effects of Mailuoning oral liquid combined with Mecobalamin tablets in treating aged diabetic peripheral neuropathy

目的观察脉络宁口服液联合甲钴胺片治疗老年糖尿病周围神经病变(DPN)的疗效。方法将49例DPN患者随机分为治疗组(n=24)和对照组(n=25)。两组患者均采用甲钴胺片治疗,治疗组加用脉络宁口服液,两组均治疗3个月。比较两组患者的多伦多临床评分系统(TCSS)评分、中医症状量化评分。根据中医症状量化评分标准判断患者疗效。结果两组患者治疗后TCSS评分均明显低于治疗前(均P<0.05)。治疗组患者治疗后的TCSS评分明显低于对照组(P<0.05)。治疗组治疗后中医症状量化评分明显低于治疗前(P<0.05)。治疗组治疗后中医症状量化评分明显低于对照组(P<0.05)。治疗组患者总有效率(88%)明显高于对照组(50%)(χ~2=6.631,P=0.01)。结论脉络宁口服液联合甲钴胺片对DPN治疗安全有效。

Objective To observe the curative effects of Mailuoning oral liquid combined with Mecobalamin tablets in treating aged diabetic peripheral neuropathy （DPN）. Methods Forty-nine patients with DPN were randomly divided into treatment group （ n = 25 ） and control group （ n = 24 ）. The patients in two groups were given Meeobalamin tablets, and the treatment group was added treated with Mailuoning oral liquid. The period of treatment was 3 months. Scores of Toronto clinical scoring system （TCSS） and traditional Chinese medicine （TCM） symptoms quantitative scale were compared between the two groups. The curative effects of all the patients were judged by the TCM symptoms quantitative scores. Results The TCSS levels in two groups after treatment were both significantly lower than those before treatment （ all P 〈 0. 05 ）. The TCSS level after treatment in treatment group was significantly lower than that in control group （ P 〈 0.05 ）. The TCM symptoms quantitative score after treatment in treatment group was significantly lower than that before treatment （ P 〈 0. 05 ）. The TCM symptoms quantitative score after treatment in treatment group was significantly lower than that in control group （ P 〈 0. 05 ）. The total effective rate in treatment group （88%） was significantly higher than that in control group （50%） （χ^2= 6. 631, P = 0. 01 ）. Conclusion Mailuoning oral liquid combined with Mecobalamin tablets is safe and effective for treating DPN.