连续流反应技术开发及其在制药危险工艺中的应用

Development and Application of Continuous-flow Technology in Pharmaceutical “Hazardous Processes”

当前,化学制药过程仍然存在许多极易导致泄漏、火灾、爆炸、中毒的工艺——"危险工艺"。传统间歇釜式生产方式存在传质传热效率低、产品质量稳定性差、生产效率低等缺点,尤其在处理"危险工艺"过程中,釜式反应过程安全隐患大。而连续流反应技术具有在线反应量少、传质传热效率高、参数控制精确、工艺稳定、安全高效等优点,能使"危险工艺"在安全高效的可控模式下运行。本文主要介绍连续流反应技术在光气及光气化、氯化、硝化等典型"危险工艺"中的成功应用案例,进一步阐明连续流反应技术的显著优点。

Currently, there are many processes in pharmaceutical industry, namely ＂hazardous processes＂,which may be easy to leak, highly flammable, or involved in explosive or toxic chemicals. Batch processes often facesome problems like low mass/heat transfer efficiency, lack of stability, low productivity, etc. Especially for ＂hazardous processes＂, batch reactors have some serious safety issues. Continuous-flow technology, in the other hand, has some advantages such as high mass/heat transfer efficiency, the precise control of reaction parameters, intrinsic safety, high productivity and equality, which make ＂hazardous processes＂ to be conducted under safe and efficient procedures.This article mainly int-roduced some applications of continuous-flow technology in typical ＂hazardous processes＂ like phosgenation, chlorination, nitration, etc.