Wnt-1和FZD-1在小细胞肺癌患者中的表达及临床意义

Expression and clinical implications of Wnt-1 and FZD-1 in small cell lung cancer patients

目的:研究Wnt-1和FZD-1在小细胞肺癌(SCLC)患者中的表达及其与化疗耐药和临床特征的关系。方法选取我院收治的41例SCLC患者,检测外周血单核细胞(PBMC)中Wnt-1和FZD-1的表达水平,分析其与SCLC临床病理学特征及预后的关系。结果化疗耐药组中Wnt-1和FZD-1的表达量均明显高于化疗敏感组(均P<0.05)。Wnt-1与FZD-1表达呈正相关(r=0.186,P<0.05)。FZD-1表达水平与肿瘤临床分期有关(P=0.008),但与患者年龄、性别、吸烟史无关(均P>0.05)。Wnt-1表达水平则与患者的病理临床特征无明显相关性(均P>0.05)。Wnt-1和FZD-1高表达与患者的中位生存时间均密切相关(均P<0.05)。结论 Wnt-1与FZD-1在SCLC患者中呈高表达,并与临床特征和耐药性相关,可以为临床提供一种简便易行的预测化疗耐药的指标。

Objective To investigate the expressions of Wnt-1 and FZD-1 in small cell lung cancer（SCLC） patients and their relations with chemotherapy resistance, clinical feature and prognosis. Methods Peripheral blood specimens were collected from 41 SCLC patients. The expression of War- 1 and FZD- 1 in peripheral blood monouelear cells （PBMC） were detected. The relationship among the expression of Wnt-1 and FZD-1, clinicopatho- logic feature and prognosis was analyzed. Results The relative expression of Wnt-1 and FZD-1 in chemotherapy resistant group was significantly higher than that in chemotherapy sensitive group （ all P 〈 0.05 ）. The expression of Wnt-lwas positively correlated with that of FZD-1 （r = 0.186, P 〈 0.05 ）. The FZD-lexpression level was not correlated with patients＇ age, sex and smoking history （all P 〉 0.05）, but closely with clinic-staging （P = 0.008）. The Wnt-1 expression level was not correlated with patients＇ clinical features （all P 〉 0.05）. There was statistical difference in median survival time between Wnt-1 and FZD-1 high-expression group and low-expression group. Conclusions Wnt-1 and FZD-lrelationships with chemotherapy resistance and prognosis. Wnt-1 and FZD-1 may act as an important role in chemotherapy resistance of SCLC and could be served as indicators for the chemotherapy resistance and outcome assessment of SCLC.