双相障碍躁狂发作患者血清甲状腺激素和垂体泌乳素水平的研究

Study of serum thyroid hormone and prolactin levels in patients with bipolar mania

目的:探讨双相障碍躁狂发作患者血清甲状腺激素和垂体泌乳素水平及与疾病的相关性。方法:40例双相障碍躁狂发作患者及40名健康对照进行促甲状腺激素(TSH)、总三碘甲状腺原氨酸(TT3)、总四碘甲状腺原氨酸(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、垂体泌乳素(PRL)血液浓度的检测,优势比(OR)计算双相障碍躁狂发作的甲状腺激素、PRL的相关程度。结果:甲状腺激素、PRL水平异常的男性病例组和女性病例组的OR分别为0.44/1.42和5.67/10.23。与男性正常组比较,男性病例组TT4水平降低(F=2.03,P<0.05),差异有统计学意义;与女性正常组比较,女性病例组TSH和PRL水平升高(Z=2.19,Z=2.03),TT3和TT4降低(F=8.66,F=6.11),差异有统计学意义(P均<0.05)。结论:双相障碍躁狂发作的女性患者TSH、PRL水平增加可能与双相障碍躁狂期发病有关,男性未发现上述现象。

Objective： To find out the interaction of hormones secreted by anterior pituitary function with bipolar mania. Method：The present cross-sectional study was processed to test the thyroid-sitmulating hormone （TSH）, total three iodine thyronine （Tl＇3）, total serum thyroxine（ TT4）, free triiodothyronine （ FT3 ）, free thyroxine （ FT4 ） and prolactin （PRL） between a total of forty patients diagnosed bipolar disorder in manic state （BD） and 40 healthy controls （ HC ）. Odd ratios （ ORs ） were calculated to find out the strength of association of serum thyroid hormone and PRL between the BD and HC. Results：The ORs of ex- ceptional value of serum thyroid hormone and PRL in male and female BD were respectively 0.44/1.42 and 4.00/10.23. TT4 of male BD was lower than male HC with statisitical significance （ F = 2. 03, P 〈 0.05 ） ; TSH and PRL of female BD were higher than female HC（Z = 2. 19 ,Z = 2.03 ） ,T13 and TT4 of female BD were lower than female HC （ F = 8.66, F = 6.11 ） with statisitical significance （ all P 〈 0.05 ）. Conclusion： The increased secretion of TSH and PRL in female patients may be responsible for the onset of BD, the above phenomenon is not found in male patients.