双相障碍患者血清超敏C反应蛋白水平的研究

Increased serum high sensitive C-reactive protein in patients with bipolar disorder

目的:了解不同双相障碍患者之间血清超敏-C反应蛋白(hs-CRP)水平的差异。方法:选取2015年1月至12月北京回龙观医院住院或门诊双相障碍患者包括145例双相障碍躁狂发作患者(躁狂组),82例抑郁发作患者(抑郁组),125例双相缓解期患者(缓解组),另有42名正常健康人为正常对照组,所有研究对象运用胶乳增强免疫透射比浊法(L-EITD)检测血清hs-CRP水平。结果:与正常对照组血清hs-CRP(0.96±0.82)mg/L相比,缓解组、抑郁组和躁狂组血清hs-CRP水平有不同程度的升高,以躁狂组血清hs-CRP显著升高[(1.1±1.6)、(2.1±2.8)、(7.3±9.4)mg/L],差异具有统计学意义(P<0.001),且不受性别因素影响。结论:双相障碍躁狂发作患者的血清hs-CRP水平显著升高,血清hs-CRP可能是双相障碍的一个生物标志物。

Objective： To investigate the level of serum high sensitive C-reactive protein （hs-CRP） in patients with different bipolar disorder（BD）. Method：Serum hs-CRP levels were assessed in 394 subjects, including 145 BD patients with mania,82 BD patients with depression,and 125 BD patients with euthymia and 42 healthy control subjects. The patients were randomly recruited from Beijing Hui-long-guan hospital, a psychiattic hospital owned by Beijing Government, during January to December,2015. Serum hs-CRP was detected by latex panicle intensified immunity transmission turbidity （L-EITD）. Results：Compared with healthy subjects, there was an elevation in the level of hsCRP in BD patients with mania,with depression and with euthymia,especially in manic BD patients [ （0.96 ±0.82）, （1.1 ± 1.6）, （2.1 ±2.8） and （7.3 ± 9.4） mg/L,respec- tively,P 〈0. 001 ]. The elevation of serum hsCRP in patients was not affected by gender （P 〉 0.05 ）. Conclusion： Patients with bipolar disorder have an elevation of sernm hsCRP levels,which may be a biomakers of bipolar disorder.