59例肺结核合并糖尿病治疗引起肾损害临床分析

Clinical analysis of 59 cases of pulmonary tuberculosis complicated with diabetes mellitus in the treatment of renal damage

目的了解肺结核(pulmonary tuberculosis PTB)合并糖尿病(diabetes mellitus,DM)的患者在治疗中肾功能功损害情况,为临床治疗提供参考依据。方法对我院收治59例PTB合并DM患者,临床应用抗结核药物而诱发肾功能损害的资料进行回顾性分析。结果 PTB合并DM的患者中的糖化血红蛋白(HbA1C)升高24人、N-乙酰-β-D氨基葡萄糖苷酶(NAG)升高36人、半胱氨酸蛋白酶抑制剂C(CysC)升高49人、视黄醇结合蛋白(RBP)升高35人;单纯PTB的患者中HbA1C升高7人、NAG升高25人、CysC升高16人、RBP升高24人,PTB合并DM的患者明显高于单纯PTB的患者,P<0.05,有统计学差异。结论 PTB合并DM治疗时应严格控制血糖水平,减少其引起的肾损害影响。

Objective To understand the renal function damage situation of patient in therapy who suffers from tuberculosis （TB） complicated by diabetes mellitus （DM） so as to offer reference basis for clinical treatment.Methods Selecting 59 cases of patients suffer from TB and DM treated in our hospital,retrospective analysis is conducted to the data of renal function damage caused by clinical application of antituberculosis drugs.Results For the patients with tuberculosis complicated by diabetes mellitus,24 people＇s glycosylated hemoglobin A1c （HbA1C） content increased,36 people＆39;s N-acetyl-β-D-glucosaminidase （NAG） content increased,49 people＆39;s cysteine proteinase inhibitor C （CysC） content increased,35 people＆39;s retinol-binding protein （RBP） content increased;for the patients with Tuberculosis only,there are 7 patients whose HbA1C increased,25 whose NAG increased,16 whose CysC increased,and 24 whose RBP increased.Therefore,the number of patients with tuberculosis complicated by diabetes mellitus is obviously higher than that of patients with tuberculosis only,P〈0.05,with significant difference.Conclusion The damage of antituberculosis drugs to the patient＆39;s kidney should be discovered as early as possible,To reduce the influence caused by treatment of renal damage of pulmonary tuberculosis with diabetes.