妊娠期高血压疾病国际研究热点的文献计量分析

Bibliometric study on international research hotspots for hypertensive disorders of pregnancy

目的通过文献计量分析方法,研究近年来妊娠期高血压疾病的国际研究热点及其分布,为把握该领域未来研究方向提供参考依据。方法以妊娠期高血压疾病为主题词,检索Pubmed数据库中在国际上发表的妊娠期高血压疾病相关文献,利用书目信息共现挖掘系统提取2005至2016年文献的主题词,生成主题词词篇矩阵;使用g CLUTO 1.0软件对矩阵进行双向聚类分析,并根据聚类分析结果生成可视化曲线山峰图及树状图。结果 Pubmed共收录妊娠期高血压疾病相关文献31 084篇,最早发表于1945年,经过两个小波峰(1945至1960年、1961至1980年)后,发表文献数量呈指数级递增。从国际范围来看,除中国之外,美国、英国、日本、德国、意大利和加拿大等国家也都是该领域的热点研究国家。聚类分析结果显示,国际研究热点主要集中在妊娠期高血压疾病的治疗、流行病学及其相关危险因素、诊断及早期预测、遗传及基因多态性、并发症及合并症的诊治、病理生理机制六个聚类中;其中子痫前期的早期预测(聚类2)是近年的核心热点,该热点的类内文章数量最多,且文章间的研究主题高度一致;次热点为妊娠期高血压疾病的治疗。结论自1945年首篇文献后,近年来妊娠期高血压疾病的文献数量呈指数级递增。国际研究热点主要集中在妊娠期高血压疾病的治疗、流行病学及其相关危险因素、诊断及早期预测、遗传及基因多态性、病理生理机制等方面,其中以疾病早期预测为核心热点。

Objective To grasp the international research hotspots of hypertensive disorder complicating pregnancy（ HDCP） and their distribution through bibliometric analysis and to provide reference for future research area on HDCP for domestic researchers. Methods Hypertensive disorders of pregnancy was used as mesh terms in searching of published international literatures related with HDCP disorders of pregnancy in Pubmed database. Then key words of literatures from 2005 to 2016 on pregnancy induced hypertension were retrieved by Bibliography Item Co-occurrence Mining System and topic word matrix was generated. Bi-clustering analysis of the matrix was carried out using g CLUTO 1. 0 software and visual curve mountain graph and tree diagram were generated based on cluster analysis. Results Altogether31 084 literatures was included in Pubmed since 1945. After two small peaks（ 1945-1960,1961-1980）,the number of published literatures showed an exponential increase. Besides China,United States,Britain,Japan,Germany,Italy and Canada and other countries were hot spots in the field of HDCP research. Results of cluster analysis showed that international research focus was mainly concentrated on six aspects,including treatment,epidemiology and risk factors,diagnosis and early prediction,genetic polymorphism,treatment and diagnosis on complications,physiopathology of HDCP. And early prediction of preeclampsia（ cluster 2） was core hotspot in recent years,with the largest number of literatures and highly consistent research theme compared to other hotspots. Secondary hotspot was treatment of HDCP. Conclusion Since the first literature in 1945,the number of literatures on hypertensive disorders of pregnancy has increased exponentially in recent years. International research hotspots are treatment,epidemiology and risk factors,diagnosis and early prediction,genetic polymorphism and physiopathology of HDCP. And early prediction of preeclampsia is the most core hotspot.