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血清同型半胱氨酸、D-二聚体及C反应蛋白对原发性肝癌的临床诊断价值 被引量:6

Diagnostic value of homocysteine,D-dimer and C-reaction protein in hepatocellular carcinoma
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摘要 目的探讨血同型半胱氨酸(Hcy)、D-二聚体和C反应蛋白(CRP)联合检测对原发性肝癌(HCC)的临床诊断价值。方法采用美国IL公司的ACL TOP全自动血凝仪及日立公司7600全自动生化分析仪对我院2012年5月至2016年5月收治的76例HCC患者和74例健康体检者的血清Hcy、D-二聚体和CRP进行检测,并进行统计学分析。结果 HCC组患者血Hcy、D-二聚体和CRP含量均明显高于健康对照组,差异具有统计学意义(P<0.05)。其中,血Hcy对HCC检测敏感度为72.37%,D-二聚体的敏感度为73.68%,CRP的敏感度为76.32%,联合检测D-二聚体和Hcy或CRP可使敏感度提高至85.53%和86.84%,三者联合检测敏感度为89.47%。结论联合检测血清Hcy、D-二聚体和CRP三项指标可明显提高HCC的诊断率。 Objective To evaluate the diagnostic value of the combined examination of homocysteine(Hcy),D-dimer and C-reaction protein(CRP)in patients with hepatocellular carcinoma(HCC).Methods The United States IL company's ACL TOP Evolution automatic blood coagulation analyzer and HIT 7600 automatic biochemical analyzer were applied to detect and compare Hcy,D-dimer and CRP in 76 patients with HCC and healthy controls in our hospital from May2012 to May 2016.Results Serum Hcy,D-dimer and CRP protein were significant higher in patients with HCC than healthy controls(P〈0.05).Besides,the sensitivity of Hcy was 72.37%,the sensitivity of D-dimer was 73.68%,the sensitivity of CRP was 76.32%,the sensitivity of combined D-dimer and Hcy or CRP were 85.53%and 86.84%,respectively,the sensitivity of Ddimer and Hcy combined CRP was 89.47%.Conclusion Combined examination of serum Hcy,D-dimer and CRP can significantly increase the diagnosis rate of HCC.
机构地区 惠州市中医医院
出处 《青岛医药卫生》 2017年第2期88-90,共3页 Qingdao Medical Journal
关键词 肝癌 同型半胱氨酸 D-二聚体 C反应蛋白 诊断 Hepatocellular carcinoma Homocysteine D-dimer C-reaction protein Diagnosis
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