基于离子交换树脂的口服液体缓释制剂的研究进展

Research Progress of Oral Liquid Sustained Release Preparation Based on Ion Exchange Resin

离子交换树脂是一种新型药用高分子材料。口服液体制剂是一种以液体混悬或乳剂形式存在,以口服方式给药的常见的药物剂型。药物制成缓释制剂是为了使药物在特定的时间内保持血药浓度恒定。离子交换树脂为载体的口服液体缓释制剂因其综合了离子交换树脂、缓释制剂和口服液体的诸多优点,近年来在国内外受到广泛关注。药物能通过交换反应吸附到离子交换树脂上形成药物树脂复合物,它通过可逆性的交换胃肠道中的离子而释放药物。此外,将药物树脂复合物包衣或微囊化能更好的控制药物释放速率。以药物树脂复合物为核心,选择适当的水不溶性但可渗透的聚合物如乙基纤维素进行包衣,可以获得更理想的缓释效果。因离子交换树脂具有控制药物释放速度、减少药物的苦味、提高药物的稳定性、降低药物不良反应等优点,被广泛应用于药物制剂中。该文主要介绍了离子交换树脂应用于口服液体缓释制剂缓释作用的原理、特点,对近几年该药物载体在口服液体缓释制剂中的研究和应用进行了综述,并对其应用前景进行了展望。

Ion exchange resin is a new kind of medical polymer biomaterial. Oral liquid preparation is a kind of common pharmaceu- tical dosage form, which exists in the form of liquid suspension or emulsiorl and for oral administration. The purpose of preparing the drug as a sustained release preparation is to maintain a constant blood drug concentration in a given period of time. In recent years, oral liquid sustained-release preparation with ion exchange resin as the carrier has been widely concerned both at home and abroad because it combines the advantage of ion exchange resin, sustained release preparation and oral liquid preparation. The drug can be adsorbed on the ion exchange resin by the exchange reaction to form a drug resin complex, which can reversibly exchange ions in the gastrointestinal tract and release drugs. Furthermore, coating or microencapsulation of drug resin complexes can better control the drug release rate. It is possible to obtain a more satisfactory slow-release effect by taking the drug resin complex as the core and selecting a suitable water insoluble but permeable polymer such as ethyl cellulose. Ion exchange resin is widely used in pharmaceutical formulations owing to the advantages of controlling the drug release rate, reducing the bitterness of the drug, improving the stability of the drug and reducing the adverse drug reaction. This article mainly introduced the sustained release principle ,characteristics of ion exchange resin as drug carrier in oral liquid sustained release preparation, reviewed its research and application progress, and expected its advancement.