N-乙酰氨基葡萄糖转移酶Ⅴ在卵巢浆液性囊腺癌中表达及临床意义

Expression and clinical significance of N-acetylglucosaminyltransferase Ⅴ in ovarian serous cystadenocarcinoma

目的探讨N-乙酰氨基葡萄糖转移酶Ⅴ(GnT-Ⅴ)在卵巢浆液性囊腺癌中的表达及临床意义。方法收集卵巢浆液性囊腺癌标本152例、卵巢浆液性囊腺瘤标本100例及卵巢交界性浆液性囊腺瘤标本20例,检测标本中GnT-Ⅴ的表达水平并分析其与卵巢浆液性囊腺癌临床病理参数的关系。结果卵巢浆液性囊腺癌GnT-Ⅴ阳性表达率25.7%(39/152)明显低于浆液性囊腺瘤67.0%(67/100)与交界性浆液性囊腺瘤45.0%(9/20);早期卵巢浆液性囊腺癌GnT-Ⅴ阳性表达率33.3%(23/69)明显高于晚期19.3%(16/83);高分化卵巢浆液性囊腺癌GnT-Ⅴ阳性表达率38.6%(22/57)明显高于中低分化17.9%(17/95),差异均有统计学意义(P<0.05)。已有淋巴结转移的卵巢浆液性囊腺癌GnT-Ⅴ阳性表达率22.9%(16/70)与无淋巴结转移的卵巢浆液性囊腺癌GnT-Ⅴ阳性表达率28.8%(23/82)比较,差异无统计学意义(P>0.05)。结论 GnT-Ⅴ在卵巢浆液性囊腺癌中表达下调,其表达水平降低可能预示着肿瘤分化程度低、预后差。

Objective To investigate the expression level and clinical significance of N-acetylglucosaminyltransferase V（ GnT-Ⅴ） in ovarian serous cystadenocarcinoma. Methods A retrospective study was performed on 152 cases of ovarian serous cystadenocarcinoma,100 cases of ovarian serous cystadenoma and 20 cases of borderline ovarian serous cystadenoma. The relationship of GnT-Ⅴ expression and clinicopathologic parameters of ovarian serous cystadenocarcinoma was analyzed. Results The positive expression rate of ovarian serous cystadenocarcinoma（ 25. 7%,39/152） was significantly lower than that of ovarian serous cystadenoma（ 67. 0%,67/100） and borderline ovarian serous cystadenoma（45. 0%,9/20）;early ovarian serous cystadenocarcinoma GnT-Ⅴ positive expression rate（33. 3%,23/69） was significantly higher than that in the late ovarian serous cystadenocarcinoma（19. 3%,16/83）;high differentiation of ovarian serous cystadenocarcinoma GnT-Ⅴ positive expression rate（38. 6%,22/57） was significantly higher than that in low differentiation（17. 9%,17/95）,and the difference had statistical significance（ P〈0. 05）. The GnT-Ⅴ positive expression rate in ovarian serous cystadenocarcinoma with lymph node metastasis was（22. 9%,16/70）,and in ovarian serous cystadenocarcinoma without lymph node metastasis was（28. 8%,23/82）,the difference was not statistically significant（P〈0. 05）. Conclusion The expression of GnT-Ⅴ is down-regulated in ovarian serous cystadenocarcinoma,which may be correlated with low degree of differentiation and poor prognosis.