血清同型半胱氨酸和B型脑钠肽水平在评估冠心病患者PCI术后左心功能中的应用价值

Application value of Hcy and BNP levels in the assessment of the left heart function of patients with coronary artery disease after PCI

目的 :探讨血清同型半胱氨酸(Hcy)和B型脑钠肽(BNP)水平在评估冠心病患者PCI术后左心功能中的应用价值。方法 :回顾性分析60例患者的临床案例,按NYHA心功能分级方法分为Ⅲ~Ⅳ级组及Ⅰ~Ⅱ级组各30例。结果 :Ⅲ~Ⅳ级组患者LVEDD、LVESD、A/E的值和血清Hcy、BNP水平均高于Ⅰ~Ⅱ级组,而LVEF值则低于Ⅰ~Ⅱ级组(P<0.05);一元线性回归法分析显示,血清Hcy、BNP水平与LVEDD、LVESD、A/E值呈正相关,而与LVEF值呈负相关(P<0.05)。结论 :血清Hcy和BNP水平可用于冠心病患者PCI术后左心功能的评估,并为患者的后续治疗提供诊疗依据。

Objective： To study the application value of serum homocysteine （Hcy） and B type natriuretic peptide （BNP） levels in the assessment of the left heart function of patients with coronary artery disease after PCI. Methods： The data from sixty cases of patients with coronary artery disease after PCI were retrospectively analyzed and they were divided into a Ⅲ-Ⅳ level group and a Ⅰ-Ⅱ level group with 30 cases each based on a method for the classification of NYHA heart function. Results： The values of LVEDD, LVESD, A/E were higher while the values of LVEF were lower in the Ⅲ-Ⅳ level group than in the Ⅰ-Ⅱ level group （P 〈0.05）. Serum Hcy and BNP levels were higher in the Ⅲ-Ⅳlevel group than in the Ⅰ-Ⅱ level group （P 〈0.05）. The analysis of the unary linear regression method showed that serum Hcy and BNP levels were positively correlated with LVEDD, LVESD, A/E values and negatively correlated with LVEF value （P〈0.05）. Conclusion： Serum Hcy and BNP levels can be used to assess left heart function of patients with coronary heart disease after PCI and to provide clinical basis for the subsequent treatment of the patients.