临床药师在静脉药物配置中心抗肿瘤药物合理应用中的作用

Role of clinical pharmacists participating in rational use of antitumor drugs at PIVAS

目的 :对我院抗肿瘤药物静脉配置不合理医嘱情况进行调查分析,探讨临床药师促进合理应用抗肿瘤药物的作用。方法 :提取我院静脉药物配置中心(PIVAS)经临床药师审核并建议修改的不合理抗肿瘤药物注射剂用药医嘱分类并统计,分析不合理用药原因,并就干预、改善不合理用药的对策进行总结。结果 :发现不合理医嘱139组,占全部医嘱的0.36%,主要不合理为载体种类和载体量、给药剂量、顺序、时间和途径、配伍禁忌,以载体种类和载体量不合理最为常见。结论 :我院临床药师通过多种对策,干预、改善抗肿瘤药物的不合理应用,为医师临床治疗决策提供帮助,协助医师合理设计化疗方案,提高药物治疗效果,规避不良反应的发生。

Objective： To investigate and analyze the irrational medical orders of antitumor medication at pharmacy intravenous admixture services （PIVAS） and explore the effect of clinical pharmacists on promoting rational use of antitumor drugs. Methods： The irrational medical orders of antitumor drugs for injection at PIVAS, which were checked and suggested to be modified by clinical pharmacists, were classified and counted and their reasons were analyzed. Meanwhile, the countermeasures for intervening and improving the irrational drug use were also summarized. Results： One hundred and thirty-nine sets of irrational medical orders （accounting for 0.36% of the total） were found and divided into seven fields such as solvent type and amount, drug dosage, administration sequence, time and route and incompatibility, in which the solvent type and amount were the most common. Conclusion： The irrational antitumor medications can be intervened and improved by clinical pharmacists through a variety of countermeasures so as to provide a help for the prescription of physicians, assist them to rationally design chemotherapy regimens, improve the clinical efficacy and avoid the occurrence of adverse drug reactions.