榄香烯乳联合顺铂腹腔灌注治疗恶性腹腔积液的临床观察

Explore the clinical efficary of elemi olefinic for the treatment of malignanl peritoned effusion

目的探讨榄香烯乳联合顺铂腹腔灌注治疗恶性腹腔积液的临床疗效.方法将确诊为恶性腹腔积液符合入组条件的64例患者随机分为治疗组(32例)和对照组(32例),应用腹腔穿刺导管行腹腔穿刺置管引流,治疗组给予榄香烯乳400~500mg/m2+顺铂60mg腹腔灌注,对照组给予顺铂60mg腹腔注射,连用4周评价治疗效果.结果64例患者均完成治疗,治疗组、对照组的有效率分别为87.5%、53.1%.组间差异P=0.003<0.05有统计学意义;治疗组、对照组不良反应率为37.5%、40.6%,组间差异P>0.05.结论榄香烯乳联合顺铂腹腔置管灌注治疗恶性腹腔积液的疗效优于单用顺铂,并且不良反应与单用顺铂无差异.

objective Explore the clinical efficacy of elemi olefinic combined cisplatin intraperito-neal injection treatment malignant peritoneal effusion.Method we randomly divided 64 malignant peritoneal effusion patients meet the conditions into treatment group（32cases）and the group of control group（32cases）,the treatment group were given elemi olefinic emulsion combine cisplatin and the control group were be given cisplatin by using the method of filling into the enterocoelia.The clinical effects of the two groups were observed after continuous medication for 4weeks.Results All of 64 patients were completed treatment,the effectiveness rate of the treatment group and control group were 87.5%,53.1%.Difference between group was statistically significant（P0.05）;The adverse reaction rate of the treatment group and control group were 37.5%,40.6%,There was no statistically significant difference between groups（P0.05）.Conclusion Implement of elemi olefinic combined cisplatin provides more precisely clinical effect in treating malignant peritoneal effusion than using cisplatin aione,and the adverse reaction has no difference both of them.