肝素结合性表皮生长因子与动脉粥样硬化关系的研究进展

Research Progress of Association of Heparin-binding Epidermal Growth Factor with Atherosclerosis

肝素结合性表皮生长因子(HB-EGF)是表皮生长因子家族中重要的一员,参与许多病理生理过程,具有促进细胞增殖、迁移、分化及信号转导等作用,与动脉粥样硬化(As)的形成密切相关,在泡沫细胞的形成、单核巨噬细胞的迁移、血管平滑肌细胞的功能发挥等过程中具有重要的作用,能够促进As的形成,与冠心病的发生密切相关,且可能有促进冠心病的发生、促进冠状动脉粥样斑块形成等作用;HB-EGF亦能够促进神经损伤的恢复,促进神经胶质细胞再生,与缺血性脑血管病密切相关。

Heparin-binding epidermal growth factor（HB-EGF） is an important member of the epidermal growth factor family. HB-EGF is involved in many pathophysiological processes, which can promote cell proliferation, migration, differ- entiation and signal transduction, and is closely related to the atherosclerosis （As） formation. HB-EGF may play an important role in the process in the formation of foam cells, mononuelear macrophage migration and the function of the vascular smooth muscle cells, it can promote the as formation. HB-EGF is closely related to the occurrence of coronary heart disease, and may promote the occurrence of coronary heart disease, promote coronary artery atheromatous plaque formation, and so on; HB-EGF can promote the recovery of nerve injury, also promote the glial cell regeneration, which is closely associated with isehemie cerebrovaseular disease.