e抗原阴性慢性乙型肝炎患者服用核苷（酸）类似物抗病毒药物依从性现状及影响因素分析

Analysis on the current situation and influencing factors of antiviral drug compliance in patients with e-antigen negative chronic hepatitis B patients who use nucleos（t）-ide analogues

目的：了解e抗原阴性慢性乙型肝炎患者服用核苷（酸）类似物抗病毒药物依从性现状并分析其影响因素。方法采用回顾性调查江苏大学附属镇江三院2008年1月—2009年12月的连续住院患者，采用电话回访、病历查询、问卷调查和门诊随访形式采集患者资料，包括一般人口资料、病史资料以及乙型肝炎知识问卷调查。结果随访采集到依从性资料患者共327例，其中依从性好的患者149例，依从性差的患者178例，依从性比例为45.57%；依从性好的患者和依从性差的患者在受教育程度、经济状况、医保种类和乙型肝炎知识知晓状况上差异有统计学意义（χ2值分别为8.372、67.488、4.592、42.071；P＜0.05）；二分类Logistic回归显示高经济收入层次、乙型肝炎知识知晓优良者等是依从性高的独立危险因素（P＜0.001）。结论 e抗原阴性慢性乙型肝炎患者服用核苷（酸）类似物抗病毒药物依从性较差，加强健康教育有利于提高其服用核苷（酸）类似物抗病毒药物依从性。

ObjectiveTo survey the effects of nucleos（t）-ide analogues on the drug compliance of patients with e-antigen negative chronic hepatitis B patients and its influencing factors.MethodsA retrospective survey was used to investigate consecutive patients who were hospitalized in our hospital from January 2008 to December 2009. Telephone interviews,medical inquiries,questionnaires and follow-ups were used to collect patients′ general information,which included general demographic information,medical history,and hepatitis B knowledge questionnaire.Results Follow-up data were collected from 327 compliance cases,which included 149 cases of good compliance and 178 cases of poor compliance. The compliance ratio was 45.57%. There were significant differences between good compliance group and poor compliance group in education background, economic status,insurance type,and the knowledge about hepatitis B （P〈0.05）. Binary Logistic regression analysis showed that high-income level,good knowledge about hepatitis B were the independent risk factors of high compliance （P〈0.001）.Conclusions The drug compliance of patients who use nucleos（t）-ide analogues to treat e-antigen negative chronic hepatitis B is poor,and we should strengthen the health education to improve the drug compliance of using nucleos（t）-ide analogues.