鼻窦炎口服液联合西药治疗急性鼻窦炎的临床观察

Effect of Nasosinusitis Oral Liquid Combined with Cefuroxime Axetil Tablets on Acute Sinusitis

目的观察鼻窦炎口服液联合头孢呋辛酯片治疗急性鼻窦炎的临床疗效。方法将190例急性鼻窦炎患者随机分为对照组和治疗组各95例,其中对照组给予头孢呋辛酯治疗,治疗组给予头孢呋辛酯治疗的基础上加用鼻窦炎口服液治疗。疗程10 d。观察两组治疗前后血清TNF-α水平及VAS评分、鼻内镜Lund-Kennedy评分、鼻窦CT Lund-Mackay评分变化。结果两组治疗后血清TNF-α水平显著下降(P<0.05),且治疗组下降幅度明显大于对照组(P<0.05);VAS评分、鼻内镜Lund-Kennedy评分、鼻窦CT Lund-Mackay评分均较治疗前显著下降(P<0.05),且治疗组下降幅度更明显(P<0.05);治疗组总有效率为88.4%,对照组为74.7%,治疗组疗效优于对照组(P<0.05)。结论鼻窦炎口服液联合头孢呋辛酯片治疗急性鼻窦炎临床疗效优于单一头孢呋辛酯治疗。

Objective To observe the clinical efficacy of nasosinusitis oral liquid （NOL） combined with cefuroxime axetil tablets （CAT） on acute sinusitis. Methods The 190 patients were randomly divided into the treatment group and control group, 95 cases in each group. The control group were treated by CAT, and the treatment group were given by NOL combined with CAT. The treatment course was for 10 days. The serum TNF-α level, the scores of VAS, Lund-Kennedy and CT Lund-Mackay were observed before and after treatment. Results The level of TNF-α of the two groups decreased significantly （P〈0.05）, and the range of the treatment group was larger than the control group （P〈0.05）. All of the scores of VAS, Lund-Kennedy and CT Lund-Mackay were lower than before treatment, and the decreased range of the treatment group was more obvioous （P〈0.05）. The effective rate of treatment group 88.42% was superior to the control group 74.74% （P〈0.05）. Conclu-sion The effect of NOL combined with CAT in treatment of acute sinusitis was better than the only CAT treatment.