灵芝及其提取物减轻肝损伤作用的研究概况

Recent Advances in Ganoderma and its Constituents on Reducing Liver Damage

灵芝为古称的"九大仙药"之一,最早的中药典籍《神农本草经》中即有收载。灵芝中含有丰富的多糖、三萜类、肽类和核苷,是其所产生临床疗效的重要物质基础。本文对灵芝及其提取物在减轻肝损伤方面的研究文献进行了整理。研究显示,灵芝及其提取物对多种有毒物质及免疫与缺血等因素造成的肝损伤均有保护作用,并在抑制肝纤维化、减轻脂肪肝形成等方面也具有良好的作用趋势,可供灵芝在临床的应用及进一步研究与开发参考。

As one of the ancient ＂Nine Heaven-sent Medicine＂, ganoderma lucidum was included in China＇s first herbal medicine book, The Classic of Herbal Medicine. Today, we have a deeper understanding on this fungus. Ganoder-ma lucidum is rich in ganoderan, triterpenes, peptides and nucleosides, which is the foundation of the herb＇s clinical effec-tiveness. In this paper, the studies on ganoderma lucidum and its constituents in reducing liver damage were analyzed. Re-searches show that ganoderma lucidum and its extracts has a protective effect on liver damage caused by toxins, immunologic reasons and ischemia. Meanwhile, it also has positive effect on controlling hepatic fibrosis and alleviating hepatic lipidosis. It provides reference for the clinical application and further research of ganoderma lucidum.