初次使用胰岛素的2型糖尿病患者发生低血糖的自身因素分析

Influence of self factors on hypoglycemia in type 2 diabetes mellitus patient with first-time insulin use

目的探讨2型糖尿病患者初次使用胰岛素发生低血糖症状的自身因素。方法选取2016年1月—12月收治的62例2型糖尿病的住院患者,均为初次使用胰岛素,存在发生低血糖症状患者24例,分为低血糖组(n=24)和非低血糖组(n=38)。对比2组相关影响因素之间的区别。结果 2组患者体质量指数(BMI)、白蛋白(Alb)、血清肌酐(Scr)、24 h尿蛋白定量、糖化血红蛋白(HbA1c)、甘油三酯(TG)、空腹C肽水平差异有统计学意义(P<0.05)。多因素回归分析发现,BMI以及HbAlc是影响低血糖症状发生的最主要保护因素,Scr以及24 h尿蛋白定量则是低血糖症状发生的危险因素。结论对于初次使用胰岛素的2型糖尿病患者,BMI和HbAlc是最为主要的影响低血糖症状发生的自身因素。

Objective To analyze the influence of self factors on hypoglycemia in type 2 dia-betes mellitus patient with first-time insulin use. Methods A total of 62 patients with type 2 dia-betes admitted to our hospital from January 2016 to December 2016 were selected, and all patients were given insulin for the first time. There were 24 patients with hypoglycemia （hypoglycemia group） and 38 patients without hypoglycemia （non-hypoglycemia group）. The difference of self factors between two groups was analyzed. Results There was a significant difference in body mass index （BMI） , albumin （Alb） , serum creatinine （Scr）, urine protein quantitation in 24 h, HbAlc and other factors between hypoglycemia and hypoglycemia, glycosylated hemoglobin （HbAlc） , hepatic triglyceride （TG） , fasting C peptide between two groups （P 〈0.05）. Multi-variate logistic regression analysis showed that BMI and HbAlc were main protective factors of hypoglycemia （P 〈0.01）. The level of Scr and urine protein quantitation in 24 h were main risk factors of hypoglycemia （P 〈0. 01） . Conclusion BMI and HbAlc are two main factors influ-encing the hypoglycemia in type 2 diabetes mellitus patient with first-time insulin use.