162例胃间质瘤内镜下治疗的临床疗效分析

Clinical Curative Effect Analysis of 162 Gastric Stromal Tumors Treated by Endoscopic Resection

目的探讨内镜下治疗胃间质瘤的安全性及有效性。方法回顾性分析我院2011年6月~2015年7月行内镜手术的162例胃间质瘤资料,瘤体直径平均1.5 cm(0.3~5.0 cm)。行内镜下黏膜下层剥离术104例,内镜下全层切除术58例,其中4例在腹腔镜监视下手术。结果并发症8例(4.9%),包括术中出血3例,术后穿孔3例,术后呼吸道感染2例。术后进流食时间平均2.7 d(1~9 d),术后住院时间平均5.4 d(2~10 d)。出院后平均随访26.4月(5~51个月),6例术后口服伊马替尼继续治疗,162例均无复发、死亡。结论内镜下切除对胃间质瘤是一种安全、有效的治疗方法。

Objective To assess the safety and effectiveness of endoscopic treatments for gastric stromal tumor. Methods Clinical data of 162 patients with gastric stromal tumor who underwent endoscopic treatments from June 2011 to July 2015 were analyzed retrospectively. The mean diameter of the tumors was 1. 5 cm（range,0. 3-5. 0 cm）. There were 104 cases of endoscopic submucosal dissection and 58 cases of endoscopic full-thickness resection. Among them,4 operations were completed under the monitor of laparoscopy. Results Complications were observed in 8 patients（4. 9%）,including 3 cases of bleeding during operations,3 cases of post-operative perforation,and 2 cases of respiratory tract infection. The mean post-operation feeding time was 2. 7 days（range,1-9 days） and post-operation hospital stay was 5. 4 days（range,2-10 days）. The mean time of follow-up was 26. 4 months（range,5-51 months）. The follow-ups showed that 6 patients receiving continuous oral administration of imatinib. No patient was found recurrence or death. Conclusion Endoscopic resection is safe and effective for gastric stromal tumors.