音猬因子信号通路与骨质疏松症关系的研究进展

Progress of the relationship between Sonic Hedgehog signaling and osteoporosis

骨发育的过程受到多种信号通路的调节,如Wnt、Notch、BMP、Hedgehog信号通路等。Hedgehog信号通路对骨形成的作用在过去的二十几年已经被证实。音猬因子(Ssonic hedgehog,Shh)在Hedgehog家族中表达最广泛,在该信号传导通路上对轴骨、四肢骨、颅面骨等骨骼的形成起着重要作用。骨质疏松症发病机制归根到底是成骨细胞的骨形成能力与破骨细胞的骨吸收之间的平衡被打破,并且成骨细胞的骨形成作用下降是其主要影响因素之一。本文主要从分子水平对Shh信号通路与影响骨质疏松症发生的几个主要因素进行综述,为Shh信号通路应用于骨质疏松的防治提供理论依据。

There are many pathways involved in bone development,such as Wnt,Notch,BMP,and Hedgehog signaling pathway.In the past 20 years,it has been proved that the Hedgehog signaling pathway is important in bone formation. Sonic hedgehog is the most widely expressed in the Hedgehog family,which is of great importance in the bone formation of axial skeleton,limb bone or craniofacial bone. The pathogenesis of osteoporosis in general is that the balance between bone formation and bone reabsorption is broken,with the decrease of osteoblast bone formation as one of the main reasons. This article reviews the relationship between sonic hedgehog and the main factors resulting in osteoporosis,in order to provide evidence for treating osteoporosis through the sonic hedgehog signaling pathway.