中药治疗骨质疏松不良反应的现状初探

Preliminary study on the adverse reactions of traditional Chinese medicine in the treatment of osteoporosis

骨质疏松症是一种以骨量低下、骨微结构破坏,导致骨脆性增加易发生骨折为特征的全身代谢性骨病,严重影响患者的生活质量。随着中国老龄化的加剧,老年人骨质疏松问题及相关治疗越来越引起重视。应用中药治疗骨质疏松具有显著的临床疗效,但临床上出现的不良反应却屡见不鲜,其危害性应引起高度重视。本文通过CNKI、万方、VIP等中文文献检索系统,归纳近几年常见中药治疗骨质疏松出现的不良反应,运用中医药理论知识和中药现代研究,以客观的态度从临床辩证、整体药性、配方剂量及疗程等方面分析其可能产生的原因,并结合国内一些专家应对方法,提出一些积极应对药物不良反应的措施,为临床用药和新药的开发提供参考。

Osteoporosis is a systemic metabolic bone disease characterized by low bone mass,destruction of bone microstructure,increased bone frailty and increased fracture risk,which can have severe influence on the patient’s quality of life. With the ageing of the Chinese population,osteoporosis in the elderly and its relevant treatment have received more and more attention. Application of traditional Chinese medicine in the treatment of osteoporosis has significant clinical efficacy,but the clinical adverse reactions are also common,and should be fully acknowledged. In this article,through searching CNKI,wanfang data info site,VIP,such as literature retrieval system,we summarized the common adverse reactions of traditional Chinese medicine in the treatment of osteoporosis in recent years. Using the theory of traditional Chinese medicine knowledge and modern TCM research method,we objectively analyzed the causes of adverse reactions from the prospects of clinical syndrome differentiation,overall medicinal properties,formulation dose and course of treatment,etc. Combined with the solutions suggested by some domestic experts,we also put forward some measures to actively cope with adverse drug reactions,in order to provide reference for clinical application and new drug development.