卒中后痫性发作及卒中后癫痫研究现状与进展

Research Status and Advances of Post-stroke Seizure and Post-stroke Epilepsy

卒中后痫性发作和卒中后癫痫的定义尚不统一,流行病学研究显示其发生率在卒中患者中为3%~30%,对卒中患者的预后有一定的影响。针对卒中后痫性发作和卒中后癫痫的治疗有卒中的治疗和二级预防以及抗癫痫药物治疗,有的研究显示新型抗癫痫药物的治疗效果优于传统药物,他汀类药物也可能降低其发生率。目前尚缺乏关于卒中后痫性发作和癫痫的诊疗共识或指南,亟待进一步研究为其提供循证医学证据。

Definition of post-stroke seizure and epilepsy remains inconsistent so far. The reported incidence of seizures after ischemic infarction varies greatly from 3% to 30%, which may exert adverse effects on clinical prognosis in stroke patients. The intervention strategies include management of stroke risk factors, stroke recurrence prevention and antiepileptic treatment. Some studies indicated that the effect of new antiepileptic drugs was superior to traditional medications, and statins might also lower the risk of occurrence. For now, there is no definite consensus or guideline for the diagnosis and treatment of post-stroke seizure and epilepsy, which requires further research to provide more evidence-based findings.