前列腺动脉栓塞联合盐酸坦索罗辛胶囊治疗良性前列腺增生的临床研究

Clinical study of prostatic artery embolization combined with tamsulosin capsules in the treatment of benign prostatic hyperplasia

目的 探讨前列腺动脉栓塞联合盐酸坦索罗辛胶囊治疗前列腺增生（BPH）的临床效果.方法 将2013年2月至2014年2月84例BPH患者采用随机数字表法分为两组.两组均择期行前列腺动脉栓塞术,对照组（42例）同时给予常规药物治疗,观察组在对照组治疗基础上给予盐酸坦索罗辛胶囊口服,两组均治疗至术后2周.采用国际症状评分（IPSS评分）、生活质量评分（QOL评分）量表分别对两组患者用药前和用药后2、3周的临床症状表现和生活质量进行评分;比较两组患者用药前和用药后3周前列腺体积大小（Vp）、最大尿流率（Qmax）及和残余尿量（RU）.结果 用药后随着用药时间的推移,两组IPSS评分及QOL评分呈降低趋势,各时间段比较差异有统计学意义（P〈0.05）;用药后3周观察组IPSS评分[（8.45±2.37）分]、QOL评分[（2.34±1.23）分]及Vp[（32.38±13.87）ml]、RU[（31.21±37.28）ml]均显著低于对照组[（11.64±3.51）分、（3.62±1.44）分、（39.76±11.63）ml、（49.62±35.43）ml],Qmax[（14.65±4.23）ml/s]显著高于对照组[（11.81±4.18）ml/s],差异均有统计学意义（P〈0.05）.结论 对进行前列腺动脉栓塞术的BPH患者,同时给予盐酸坦索罗辛胶囊治疗可显著降低IPSS评分及QOL评分,改善膀胱功能,疗效尤佳,可在临床上推广.

Objective To investigate the clinical effect of prostatic artery embolization combined with tamsulosin capsules on benign prostatic hyperplasia（BPH）.Methods Eighty-four BPH inpatients from February 2013 to February 2014 were divided into two groups.Two groups received selective prostatic artery embolization;the control group（42 cases） received conventional drug treatment, the observation group was given oral tamsulosin capsules on the basis of the control group, two groups were treated to postoperative 2 weeks.International symptom score（IPSS）, quality of life（QOL） scale were used to evaluate the clinical symptom performance and quality of life before the medication and after 2, 3 weeks of medication;prostate volume（Vp）, maximal urinary flow rate（Qmax） and residual urine volume（RU） before the medication and after 3 weeks of medication in the two groups were compared.Results Over medication time, IPSS and QOL scores in the two groups after the medication decreased, there was significant difference in the different times（P〈0.05）;IPSS[（8.45±2.37）scores], QOL[（2.34±1.23）scores] and Vp[（32.38±13.87）ml], RU[（31.21±37.28）ml] in the observation group after 3 weeks of medication were significantly lower than those in the control group [（11.64±3.51）scores, （3.62±1.44）scores, （39.76±11.63）ml, （49.62±35.43）ml, P〈0.05], Qmax [（14.65±4.23）ml/s] was significantly higher than that in the control group [（11.81±4.18）ml/s, P〈0.05].Conclusions Giving BPH patients who received prostatic artery embolization tamsulosin capsules can significantly decrease IPSS and QOL scores, improve function of the bladder with better efficacy, can be popularized in clinic.