伴抑郁、焦虑的阻塞性睡眠呼吸暂停低通气综合征患者多导睡眠图分析

Analysis of polysomnography of obstructive sleep apnea hypopnea syndrome patients with depression and anxiety

目的探讨伴有抑郁、焦虑的阻塞性睡眠呼吸暂停综合征患者多导睡眠图的特点。方法研究2014年4月至2016年10月到本院就诊的习惯性打鼾者进行多导睡眠图检查,这些患者进行多导睡眠图之前均进行Zung抑郁自评量表、Zung焦虑自评量表、匹兹堡睡眠质量指数等检查,其中55例确诊为阻塞性睡眠呼吸暂停低通气综合征的患者,将这55例患者分为两组,伴有抑郁和/或焦虑患者30例(研究组),不伴抑郁、焦虑症状患者25例(对照组)。结果 1)家族史、年龄、性别、饮酒、吸烟、高血压病、糖尿病、心脏病、脑血管病、高脂血症等两组患者差异无统计学意义(P>0.05)。2)匹兹堡睡眠质量指数研究组各指标平均值均高于对照组,但两组间差异无统计学意义(P>0.05)。3)所有入组的阻塞性睡眠呼吸暂停低通气综合征患者中有90.9%存在多导睡眠图睡眠结构紊乱,总睡眠时间及睡眠效率,研究组比对照组下降更多(P<0.05),觉醒时间,研究组组比对照组增加更多(P<0.05)。结论伴有抑郁和/或焦虑症状的阻塞性睡眠呼吸暂停综合征患者睡眠结构紊乱更严重,结果提示睡眠质量与情绪障碍密切相关,多导睡眠图能够客观体现阻塞性睡眠呼吸暂停低通气综合征患者所出现睡眠结构紊乱问题,对临床相应的干预治疗提供帮助。

Objective To assess the characteristic of obstructive sleep apnea hypopnea syndrome patients with depressionand anxiety. Methods The study included habitual snore patients who were diagnosed at our hospital during April 2014 to Octo- ber 2016, by means of the examination with polysomnography. The patients were examined with Zung self-rating depression scale, anxiety scale, Pittsburgh Sleep Quality Index before polysomnography, among them the fifty-five patients were made a definite diagnosis with obstructive sleep apnea hypopnea syndrome. These patients were divided into two groups, among them patients with depression and/or anxiety syndrome were thirty cases （study group）, the patients without depression and anxiety symptom were twenty-five cases （control group）. Results 1. No significant difference was found between the two groups re garding to family history, age, sex, drinking, smoking, hypertensive disease, diabetes mellitus, heart disease, cerebrovascular disease, hyperlipidemia （all P〉0.05）. 2. For each index of pittsburgh sleep quality index, the study group scored higher than with the control gloup, however, no significant difference was found between the two groups （P〉0.05）. 3. Disorder in poly- somnography sleep structure existed in 90.9% of all obstructive sleep apnea hypopnea syndrome patients. Compared with the control group, the total sleep time in the study group was less significantly （P〈0.05）, effective sleep time （%） was less （P〈 0.05）, wakening time was increase （P〈0.05）. Conclusion The obstructive sleep apnea hypopnea syndrome patients of depres sion and/or antiety symptom is more serious in sleep structure disorder, the results suggest the sleep quality is closely associated with mood disorders. Polysomnography provids reliable and objective basis in sleep structure disorder problem of the obstructive sleep apnea hypopnea syndrome patients, and offers help to the clinical intervention treatment.